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- W1134476506 abstract "The facultative intracellular bacterium Listeria monocytogenes has been used for decades as a model infectious agent for the study of host innate and adaptive immunity. This chapter focuses on describing what is currently known about how L. monocytogenes mediates the transition from saprophyte to mammalian pathogen and explores the regulatory circuit governed by a transcriptional activator known as PrfA that allows the bacterium to flourish in both soil and cytosol. In healthy individuals, disease caused by L. monocytogenes is usually self-limiting and presents as a form of mild gastroenteritis. The primary route of L. monocytogenes infection is translocation across the intestinal epithelium following the consumption of contaminated food products. The correct compartmentalization of broad range phospholipase C (PC-PLC) activity is important for avoiding damage to host cell membranes and is a critical aspect of L. monocytogenes virulence. L. monocytogenes strains containing prfA* mutations are hyperinvasive, are quicker to mediate phagosome escape, and initiate bacterial actin-based motility more rapidly to promote cell-to-cell spread. Microarray analyses of L. monocytogenes wild-type and prfA* mutants grown in brain heart infusion broth suggest the possibility of at least 145 or more additional genes associated with PrfA regulation. PrfA activation appears to function as the switch that enables L. monocytogenes to transition from saprophyte to pathogen. In contrast to carbon sources encountered within the host, PrfA-dependent gene expression is dramatically repressed in the presence of cellobiose and other readily metabolized sugars that are likely to be more prevalent in environments located outside of host cells." @default.
- W1134476506 created "2016-06-24" @default.
- W1134476506 creator A5019729277 @default.
- W1134476506 creator A5068870381 @default.
- W1134476506 date "2016-09-19" @default.
- W1134476506 modified "2023-09-26" @default.
- W1134476506 title "PrfA and the Listeria monocytogenes Switch from Environmental Bacterium to Intracellular Pathogen" @default.
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