Matches in SemOpenAlex for { <https://semopenalex.org/work/W113472206> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W113472206 endingPage "15" @default.
- W113472206 startingPage "406" @default.
- W113472206 abstract "The safety, tolerability, pharmacokinetics and efficacy of nelarabine were evaluated in adult and pediatric patients with relapsed or refractory T-ALL/T-LBL. Adult patients received nelarabine i.v. over 2 hours on days 1, 3 and 5 in every 21 days, and pediatric patients received this regimen over 1 hour for 5 consecutive days in every 21 days. Safety was evaluated in 7 adult and 6 pediatric patients. Adverse events (AEs) were reported in all patients. Most frequently reported AEs included somnolence and nausea in adult patients and leukopenia and lymphocytopenia in pediatric patients. Five grade 3/4 AEs were reported in both adult and pediatric patients, most of which were hematologic events. There were no dose-limiting toxicities. Efficacy was evaluated in 7 adult and 4 pediatric patients. Complete response was noted in 1 adult and 2 pediatric patients. Higher intracellular ara-GTP concentrations were suggested to be associated with efficacy. Japanese adult and pediatric patients with T-ALL/T-LBL well tolerated nelarabine treatment, warranting further investigation." @default.
- W113472206 created "2016-06-24" @default.
- W113472206 creator A5019098042 @default.
- W113472206 creator A5025070697 @default.
- W113472206 creator A5027788358 @default.
- W113472206 creator A5036000764 @default.
- W113472206 creator A5063488239 @default.
- W113472206 creator A5069304433 @default.
- W113472206 creator A5075745947 @default.
- W113472206 creator A5082712593 @default.
- W113472206 creator A5087199917 @default.
- W113472206 creator A5090854036 @default.
- W113472206 date "2011-06-01" @default.
- W113472206 modified "2023-09-28" @default.
- W113472206 title "[Phase I study of nelarabine in patients with relapsed or refractory T-ALL/T-LBL]." @default.
- W113472206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21737993" @default.
- W113472206 hasPublicationYear "2011" @default.
- W113472206 type Work @default.
- W113472206 sameAs 113472206 @default.
- W113472206 citedByCount "3" @default.
- W113472206 countsByYear W1134722062013 @default.
- W113472206 countsByYear W1134722062014 @default.
- W113472206 crossrefType "journal-article" @default.
- W113472206 hasAuthorship W113472206A5019098042 @default.
- W113472206 hasAuthorship W113472206A5025070697 @default.
- W113472206 hasAuthorship W113472206A5027788358 @default.
- W113472206 hasAuthorship W113472206A5036000764 @default.
- W113472206 hasAuthorship W113472206A5063488239 @default.
- W113472206 hasAuthorship W113472206A5069304433 @default.
- W113472206 hasAuthorship W113472206A5075745947 @default.
- W113472206 hasAuthorship W113472206A5082712593 @default.
- W113472206 hasAuthorship W113472206A5087199917 @default.
- W113472206 hasAuthorship W113472206A5090854036 @default.
- W113472206 hasConcept C121332964 @default.
- W113472206 hasConcept C126322002 @default.
- W113472206 hasConcept C142424586 @default.
- W113472206 hasConcept C187212893 @default.
- W113472206 hasConcept C197934379 @default.
- W113472206 hasConcept C2777761686 @default.
- W113472206 hasConcept C2777990475 @default.
- W113472206 hasConcept C2778375690 @default.
- W113472206 hasConcept C2780580376 @default.
- W113472206 hasConcept C2780873365 @default.
- W113472206 hasConcept C2781413609 @default.
- W113472206 hasConcept C29730261 @default.
- W113472206 hasConcept C71924100 @default.
- W113472206 hasConcept C87355193 @default.
- W113472206 hasConceptScore W113472206C121332964 @default.
- W113472206 hasConceptScore W113472206C126322002 @default.
- W113472206 hasConceptScore W113472206C142424586 @default.
- W113472206 hasConceptScore W113472206C187212893 @default.
- W113472206 hasConceptScore W113472206C197934379 @default.
- W113472206 hasConceptScore W113472206C2777761686 @default.
- W113472206 hasConceptScore W113472206C2777990475 @default.
- W113472206 hasConceptScore W113472206C2778375690 @default.
- W113472206 hasConceptScore W113472206C2780580376 @default.
- W113472206 hasConceptScore W113472206C2780873365 @default.
- W113472206 hasConceptScore W113472206C2781413609 @default.
- W113472206 hasConceptScore W113472206C29730261 @default.
- W113472206 hasConceptScore W113472206C71924100 @default.
- W113472206 hasConceptScore W113472206C87355193 @default.
- W113472206 hasIssue "6" @default.
- W113472206 hasLocation W1134722061 @default.
- W113472206 hasOpenAccess W113472206 @default.
- W113472206 hasPrimaryLocation W1134722061 @default.
- W113472206 hasRelatedWork W1833952634 @default.
- W113472206 hasRelatedWork W2007986200 @default.
- W113472206 hasRelatedWork W2155661522 @default.
- W113472206 hasRelatedWork W2375152925 @default.
- W113472206 hasRelatedWork W2412581125 @default.
- W113472206 hasRelatedWork W2549289957 @default.
- W113472206 hasRelatedWork W2588998274 @default.
- W113472206 hasRelatedWork W2793900558 @default.
- W113472206 hasRelatedWork W3145917019 @default.
- W113472206 hasRelatedWork W4286299650 @default.
- W113472206 hasVolume "52" @default.
- W113472206 isParatext "false" @default.
- W113472206 isRetracted "false" @default.
- W113472206 magId "113472206" @default.
- W113472206 workType "article" @default.