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• W1134976444 abstract "Abstract The inhibitory effect of methanol extracts of Brachystegia eurycoma and Detarium microcarpum seeds flours on some key enzymes [α-amylase, α-glucosidase and aldose reductase (AR)] linked to the pathology and complications of type 2 diabetes (T2D); and their antioxidant properties were evaluated. The antioxidant properties evaluated were DPPH and ABTS + scavenging abilities, reducing power, and antioxidant phytochemicals (total phenolics, tannins, total flavonoids and total saponins). Extracts of both flours inhibited α-amylase, α-glucosidase and AR in a dose-dependent manner. The half-maximal inhibitory concentrations (IC 50 ) of B. eurycoma on α-amylase, α-glucosidase, AR and lipid peroxidation were lower than those of D. microcarpum , indicating that it had stronger inhibitory potency than D. microcarpum . B. eurycoma also had significantly ( P and ABTS + scavenging abilities, and reducing power than D. microcarpum . The antioxidant phytochemicals (total phenolics, tannins, total flavonoids and total saponins) were also significantly ( P B. eurycoma than D. microcarpum . The inhibitory effect of B. eurycoma and D. microcarpum extracts on α-amylase, α-glucosidase and AR activities may be attributed to the combined action of their polyphenols and total saponins, and this may be a possible mechanism of action providing support for their use in managing hyperglycemia and the complications of T2D." @default.
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• W1134976444 date "2015-12-01" @default.
• W1134976444 modified "2023-09-27" @default.
• W1134976444 title "Methanol extracts of Brachystegia eurycoma and Detarium microcarpum seeds flours inhibit some key enzymes linked to the pathology and complications of type 2 diabetes in vitro" @default.
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• W1134976444 doi "https://doi.org/10.1016/j.fshw.2015.08.002" @default.
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