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- W1135581161 abstract "目的：探讨基质金属蛋白酶-2（matrix metalloproteinase-2,MMP-2）、基质金属蛋白酶-9（matrix metalloproteinase-9,MMP-9）和血管内皮生长因子（vascular endothelial growth factor,VEGF）在视网膜母细胞瘤（retinoblastoma,RB）中的表达及其与RB分化程度和视神经浸润的关系。方法：采用免疫组化方法检测40例RB中MMP-2、MMP-9和VEGF的表达。结果：40例RB中MMP-2、MMP-9和VEGF的阳性表达率分别为52.5%、57.5%和72.5%。未分化型RB中MMP-2、MMP一9和VEGF的阳性表达均高于分化型（P〈0.05）;有视神经浸润的RB中MMP-2、MMP-9和VEGF的阳性水平均高于无视神经浸润的RB（P〈0.05）。RB中MMP-2、MMP-9和VEGF的表达呈正相关关系（P〈0.05）。结论：RB中MMP-2、MMP-9和VEGF高表达与RB的浸润和转移相关,且MMP-2、MMP-9表达与VEGF表达存在相关性。联合检测MMP-2、MMP-9和VEGF的表达可作为反映RB浸润、转移潜能的生物学指标,有助于筛选转移高危病例及评价患者预后。" @default.
- W1135581161 created "2016-06-24" @default.
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- W1135581161 date "2010-01-01" @default.
- W1135581161 modified "2023-09-28" @default.
- W1135581161 title "视网膜母细胞瘤中MMP-2、MMP-9和VEGF的检测及意义" @default.
- W1135581161 hasPublicationYear "2010" @default.
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