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- W1135670135 abstract "The association between exposure to asbestos fibers and the development of lung cancer and mesothelioma is well-established in both man and experimental animals. The fact that asbestos—a known and highly durable carcinogen that has been used extensively in industry and households for decades—continues to pose an important health concern even though the US Environmental Protection Agency has restricted the industrial use of asbestos since the early 1970s. Asbestos is a well established human carcinogen and, as exemplified by the recent Libby, Montana incidence, the danger of developing asbestos associated disease has extended beyond that of a simple occupational setting. Various in vitro and in vivo studies suggest that fiber dimensions, surface properties, and physical durability are important criteria for the carcinogenicity of the fibers. The correlation between fiber dimension and carcinogenic potency suggests the importance of fiber–cell interactions. The carcinogenic mechanism of asbestos is complex and no single pathway can account for all of the known effects of asbestos fibers. It is likely that multiple pathways involving physical interaction of asbestos and the target cells and the subsequent inflammatory response are important in the initiation of diseases. A better understanding of the carcinogenic mechanism of asbestos and other mineral fibers provide important information on interventional and preventive measures in the management of asbestos mediated human diseases." @default.
- W1135670135 created "2016-06-24" @default.
- W1135670135 creator A5067197557 @default.
- W1135670135 date "2009-01-01" @default.
- W1135670135 modified "2023-09-23" @default.
- W1135670135 title "Chapter 2 Mechanism of Fiber Carcinogenesis" @default.
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- W1135670135 doi "https://doi.org/10.1016/s1872-0854(09)00002-2" @default.
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