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- W1135839845 abstract "Optimization of lead compound 1, through extensive use of structure-based design and a focus on PI3Kδ potency, isoform selectivity, and inhaled PK properties, led to the discovery of clinical candidates 2 (GSK2269557) and 3 (GSK2292767) for the treatment of respiratory indications via inhalation. Compounds 2 and 3 are both highly selective for PI3Kδ over the closely related isoforms and are active in a disease relevant brown Norway rat acute OVA model of Th2-driven lung inflammation." @default.
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- W1135839845 date "2015-09-03" @default.
- W1135839845 modified "2023-10-01" @default.
- W1135839845 title "Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease" @default.
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- W1135839845 doi "https://doi.org/10.1021/acs.jmedchem.5b00767" @default.
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