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• W113692597 abstract "The lipid mediators of inflammation include diverse biologically active molecules, mainly eicosanoids, but also phospholipids that modulate functional responses of inflammatory cells, i.e., adherence, locomotion, phagocytosis, production of reactive oxygen species, release of lysosomal enzymes, and synthesis of cytokines and other mediators. Lipid mediators also regulate important events of the inflammatory process, such as leukocyte trafficking, vascular permeability and smooth muscle contractility (1–3). Thus, lipid mediators play important roles in the regulation of the inflammatory process in health, in which they mediate immune response and promote tissue repair, as well as in inflammatory diseases, in which the dysregulation of their biosynthesis and/or activity results in tissue damage and other deleterious effects. Among many lipid mediators, PG E2 (PGE2), which is produced either by the constitutive cyclooxygenase (COX-1) or the inducible cyclooxygenase (COX-2), plays an important role in the regulation of phagocyte activity and acts as a potent vasodilator. Leukotriene B4 (LTB4) derived from the 5-lipoxygenase (5-LO) pathway is a potent chemoattractant for phagocytes and is likely an important component of body defense mechanisms against infection. LTB4 has also been recently involved in the development of inflammation in collagen-induced arthritis in mice (4), an animal model of rheumatoid arthritis. The cysteinyl-LT (LTC4, D4, and E4), also derived from the 5-LO pathway, are potent stimuli of vascular permeability and have been clearly implicated as mediators of the bronchospasm in asthma (5). Lipoxin A4 (LXA4), synthesized through the 5-LO and the 12- or 15-LO pathways, has been shown to act as a downregulator of phagocyte migration and is therefore believed to be part of the complex network of mediators that regulate leukocyte trafficking in inflammation (6)." @default.
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• W113692597 date "1999-01-01" @default.
• W113692597 modified "2023-10-12" @default.
• W113692597 title "Quantitative Studies of the Lipid Mediators of Inflammation Using Liquid Chromatography-Electrospray Mass Spectrometry" @default.
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• W113692597 doi "https://doi.org/10.1007/978-1-59259-253-1_13" @default.
• W113692597 hasPublicationYear "1999" @default.
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