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• W1137716852 abstract "Objectives: We present a new plasmid (pOW16C2) with a novel Tn3-like transposon harboring blaVIM-1 from a Klebsiella pneumoniae strain isolated from river water in Switzerland. Methods: Complete nucleotide sequence of pOW16C2 was obtained using a Pacific Biosciences SMRT sequencing approach and coding sequences were predicted. Results: The 59,228 bp sequence included a typical IncN-like backbone and a mosaic structure with blaVIM-1, aacA4, aphA15, aadA1, catB2, qnrS1, sul1, and dfrA14 conferring resistance to carbapenems and other β-lactam antibiotics, aminoglycosides, chloramphenicol, quinolones, sulfonamides, and trimethoprim, respectively. Most of these resistance genes were inserted in a class 1 integron that was embedded in a novel Tn3-like composite transposon. Conclusions: IncN plasmids carrying carbapenemases are frequently isolated from K. pneumoniae strains in clinical settings. The dissemination of K. pneumoniae harboring blaVIM-1 in surface water is a cause for increased concern to public health." @default.
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• W1137716852 date "2015-02-01" @default.
• W1137716852 modified "2023-10-14" @default.
• W1137716852 title "A Novel Tn<i>3</i>-Like Composite Transposon Harboring<i>bla</i>_VIM-1in<i>Klebsiella pneumoniae</i>spp.<i>pneumoniae</i>Isolated from River Water" @default.
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• W1137716852 doi "https://doi.org/10.1089/mdr.2014.0055" @default.
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