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• W1137818161 endingPage "302" @default.
• W1137818161 startingPage "249" @default.
• W1137818161 abstract "Publisher Summary The activation by specific ligands of essentially all classes of lymphocytes can cause the hydrolysis of phospholipid phosphatidylinositol 4,5-bisphosphate (PtdlnsP­2), with the transient accumulation of inositol 1,4,5-trisphosphate [Ins( 1,4,5)P3], and the elevation of [Ca2+]i in a manner closely analogous to that occurring during the activation of many other types of cells. In both T cells and B cells, there is a considerable amount of data indicating that G proteins couple activated receptors to a PtdlnsP2,-specific phospholipase C, although at present the evidence is indirect. At least one other PtdIns metabolite, Ins( l,3,4,5)P4, may play a role in sustaining [Ca2+]i at the elevated levels commonly observed after stimulation. There is suggestive, but not definitive, evidence that these very rapid responses may be necessary for the stimulation of differentiation and proliferation. Lymphocytes possess receptors that, under certain conditions, are capable of delivering negative signals to the cell by inhibiting PtdInsP2 hydrolysis and the [Ca2+]i response." @default.
• W1137818161 created "2016-06-24" @default.
• W1137818161 creator A5002205579 @default.
• W1137818161 creator A5039947845 @default.
• W1137818161 creator A5074326062 @default.
• W1137818161 creator A5074583595 @default.
• W1137818161 date "1990-01-01" @default.
• W1137818161 modified "2023-09-23" @default.
• W1137818161 title "Chapter 11 Phosphoinositide Metabolism in Lymphocyte Activation" @default.
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