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• W1137897295 abstract "I N T R O D U C T I O N 11 R E V I E W O F T H E L I T E R A T U R E 12 1 Drug interactions 12 1.1 Pharmacokinetic drug interactions 12 1.2 Pharmacodynamic drug interactions 13 2 Drug metabolism and transport 14 2.1 CYP enzyme system 14 2.2 Conjugating enzymes 24 2.3 Drug transporters 24 3 In vitro studies on drug metabolism 28 3.1 In vitro systems 28 3.2 Enzyme kinetics 29 3.3 Identification of CYP enzymes responsible for drug metabolism ....30 3.4 Characterising the inhibitory properties of drugs 30 3.5 In vitro-in vivo extrapolation 31 4 Repaglinide in the treatment of type 2 diabetes 33 4.1 Treatment principles of type 2 diabetes mellitus 33 4.2 Repaglinide 34 5 Drugs studied with repaglinide in vivo 38 5.1 Bezafibrate and fenofibrate (Study II) 38 5.2 Trimethoprim (Study III) 38 5.3 Cyclosporine (Study IV) 38 5.4 Telithromycin (Study V) 39 5.5 Montelukast (Study V) 39 5.6 Pioglitazone (Study VI) 40 A I M S O F T H E S T U D Y 42 M A T E R I A L S A N D M E T H O D S 43 1 In vitro studies 43 1.1 Design of in vitro studies 43 1.2 Determination of drug concentrations 45 1.3 Data analysis 45 2 In vivo studies 47 2.1 Design of in vivo studies 47 2.2 Subjects 47 2.3 Blood sampling 47 2.4 Determination of drug concentrations 49 2.5 Pharmacokinetic calculations 50 2.6 Pharmacodynamic variables 50 2.7 Genotyping 51" @default.
• W1137897295 created "2016-06-24" @default.
• W1137897295 creator A5053792918 @default.
• W1137897295 date "2006-12-15" @default.
• W1137897295 modified "2023-09-24" @default.
• W1137897295 title "Pharmacokinetic interactions affecting the antidiabetic repaglinide" @default.
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