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• W1138142008 abstract "Publisher Summary This chapter describes that L10 and target cells L2–L6, isolated from adult ganglia and cocultured under the same in vitro conditions as their juvenile counterparts, show a marked reduction in forming chemical synapses. The adult cells, however, can form chemical connections indistinguishable from those formed by juvenile neurons when they are cocultured with juvenile neurons. The methods used for the isolation and maintenance of Aplysia neurons in culture have been described in the chapter. During development, synapse formation between a neuron and its specific target occurs via a multistep process that includes axon growth toward the appropriate region, the formation and stabilization of appropriate connections, and the elimination of inappropriate connections. The chapter provides results on synapse formation between juvenile cells and adult cells in vitro . The results indicate that synapse formation among adult cells is significantly reduced when cultured alone. When they are plated in the presence of juvenile neurons, either target cells of L10 (left upper quadrant cells) or nontarget cells (right upper quadrant cells), synapse formation between adult L10 and adult left upper quadrant cells is enhanced." @default.
• W1138142008 created "2016-06-24" @default.
• W1138142008 creator A5072142248 @default.
• W1138142008 creator A5070490069 @default.
• W1138142008 date "1987-01-01" @default.
• W1138142008 modified "2023-09-23" @default.
• W1138142008 title "Chapter 23 Formation of chemical synapses by adult Aplysia neurons in vitro is facilitated by the presence of juvenile neurons" @default.
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• W1138142008 doi "https://doi.org/10.1016/s0079-6123(08)61831-2" @default.
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