Matches in SemOpenAlex for { <https://semopenalex.org/work/W113887752> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W113887752 endingPage "477" @default.
- W113887752 startingPage "473" @default.
- W113887752 abstract "Therapeutic preparations of desmopressin for parenteral use contain the preservative chlorobutanol (5 mg/ml). We show here that chlorobutanol is a potent inhibitor of platelet aggregation and release. It exhibited a significant inhibitory activity toward several aggregation inducers in a concentration- and time-dependent manner. Thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin respectively were markedly inhibited by chlorobutanol. Chlorobutanol had no effect on elastase-treated platelets and its antiplatelet effect could be reversed. It is concluded that the antiplatelet effect of chlorobutanol is mainly due to its inhibition on the arachidonic acid pathway but it is unlikely to have a nonspecific toxic effect. This antiplatelet effect of chlorobutanol suggests that desmopressin, when administered for improving hemostasis, should not contain chlorobutanol as a preservative." @default.
- W113887752 created "2016-06-24" @default.
- W113887752 creator A5001304900 @default.
- W113887752 creator A5018790712 @default.
- W113887752 creator A5034755642 @default.
- W113887752 creator A5048143810 @default.
- W113887752 creator A5053972239 @default.
- W113887752 date "1990-01-01" @default.
- W113887752 modified "2023-09-27" @default.
- W113887752 title "Chlorobutanol, a Preservative of Desmopressin, Inhibits Human Platelet Aggregation and Release In Vitro" @default.
- W113887752 cites W122341406 @default.
- W113887752 cites W1499223801 @default.
- W113887752 cites W1546132586 @default.
- W113887752 cites W1985107806 @default.
- W113887752 cites W1991396023 @default.
- W113887752 cites W2010694924 @default.
- W113887752 cites W2012214760 @default.
- W113887752 cites W2030087792 @default.
- W113887752 cites W2035423234 @default.
- W113887752 cites W2045594638 @default.
- W113887752 cites W2046658304 @default.
- W113887752 cites W2068672437 @default.
- W113887752 cites W2100646356 @default.
- W113887752 cites W2113943014 @default.
- W113887752 cites W2141260882 @default.
- W113887752 cites W2143112170 @default.
- W113887752 cites W2333328730 @default.
- W113887752 cites W2344606374 @default.
- W113887752 cites W2415000647 @default.
- W113887752 cites W55844027 @default.
- W113887752 doi "https://doi.org/10.1055/s-0038-1647339" @default.
- W113887752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2096493" @default.
- W113887752 hasPublicationYear "1990" @default.
- W113887752 type Work @default.
- W113887752 sameAs 113887752 @default.
- W113887752 citedByCount "6" @default.
- W113887752 countsByYear W1138877522017 @default.
- W113887752 crossrefType "journal-article" @default.
- W113887752 hasAuthorship W113887752A5001304900 @default.
- W113887752 hasAuthorship W113887752A5018790712 @default.
- W113887752 hasAuthorship W113887752A5034755642 @default.
- W113887752 hasAuthorship W113887752A5048143810 @default.
- W113887752 hasAuthorship W113887752A5053972239 @default.
- W113887752 hasConcept C126322002 @default.
- W113887752 hasConcept C134018914 @default.
- W113887752 hasConcept C181199279 @default.
- W113887752 hasConcept C185592680 @default.
- W113887752 hasConcept C2775859304 @default.
- W113887752 hasConcept C2777292125 @default.
- W113887752 hasConcept C2777399203 @default.
- W113887752 hasConcept C2778078955 @default.
- W113887752 hasConcept C2778589496 @default.
- W113887752 hasConcept C2781024287 @default.
- W113887752 hasConcept C2781080829 @default.
- W113887752 hasConcept C2993802102 @default.
- W113887752 hasConcept C55493867 @default.
- W113887752 hasConcept C71924100 @default.
- W113887752 hasConcept C89560881 @default.
- W113887752 hasConcept C98274493 @default.
- W113887752 hasConceptScore W113887752C126322002 @default.
- W113887752 hasConceptScore W113887752C134018914 @default.
- W113887752 hasConceptScore W113887752C181199279 @default.
- W113887752 hasConceptScore W113887752C185592680 @default.
- W113887752 hasConceptScore W113887752C2775859304 @default.
- W113887752 hasConceptScore W113887752C2777292125 @default.
- W113887752 hasConceptScore W113887752C2777399203 @default.
- W113887752 hasConceptScore W113887752C2778078955 @default.
- W113887752 hasConceptScore W113887752C2778589496 @default.
- W113887752 hasConceptScore W113887752C2781024287 @default.
- W113887752 hasConceptScore W113887752C2781080829 @default.
- W113887752 hasConceptScore W113887752C2993802102 @default.
- W113887752 hasConceptScore W113887752C55493867 @default.
- W113887752 hasConceptScore W113887752C71924100 @default.
- W113887752 hasConceptScore W113887752C89560881 @default.
- W113887752 hasConceptScore W113887752C98274493 @default.
- W113887752 hasIssue "03" @default.
- W113887752 hasLocation W1138877521 @default.
- W113887752 hasLocation W1138877522 @default.
- W113887752 hasOpenAccess W113887752 @default.
- W113887752 hasPrimaryLocation W1138877521 @default.
- W113887752 hasRelatedWork W1964027757 @default.
- W113887752 hasRelatedWork W1994291110 @default.
- W113887752 hasRelatedWork W2011944663 @default.
- W113887752 hasRelatedWork W2020610303 @default.
- W113887752 hasRelatedWork W2034849099 @default.
- W113887752 hasRelatedWork W2134266856 @default.
- W113887752 hasRelatedWork W2410076995 @default.
- W113887752 hasRelatedWork W293113631 @default.
- W113887752 hasRelatedWork W4240181524 @default.
- W113887752 hasRelatedWork W4880839 @default.
- W113887752 hasVolume "64" @default.
- W113887752 isParatext "false" @default.
- W113887752 isRetracted "false" @default.
- W113887752 magId "113887752" @default.
- W113887752 workType "article" @default.