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- W113896241 abstract "As with any conventional drug, the body's response to cationic lipid-DNA complexes is highly dependent on both the dose administered and the route of delivery. At relatively low doses there is little to no effect on organ function or tissue architecture, but at higher doses, acute inflammation and tissue damage can occur that is sometimes quite profound. Of the two most common routes of delivery, intravenous (IV) or intrapulmonary, IV administration tends to cause more severe adverse effects and can be lethal at higher doses of complex. Both routes activate an innate immune response that includes the induction of proinflammatory cytokines and immune cell activation, a major portion of which has been attributed to the presence of immunostimulatory CpG motifs within the plasmid DNA vector. Removing CpGs from the plasmid vector reduces several, but not all of the acute inflammatory responses to cationic lipid-DNA complexes. Therefore, other strategies are required to improve the therapeutic potential of these vectors, such as transient immune suppression, aerosolization of the complex, and novel formulations that have increased efficiency of transduction and decreased interaction with immune cells." @default.
- W113896241 created "2016-06-24" @default.
- W113896241 creator A5041655105 @default.
- W113896241 creator A5079813508 @default.
- W113896241 date "2005-01-01" @default.
- W113896241 modified "2023-09-23" @default.
- W113896241 title "Toxicity of Cationic Lipid‐DNA Complexes" @default.
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- W113896241 doi "https://doi.org/10.1016/s0065-2660(05)53007-4" @default.
- W113896241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16243064" @default.
- W113896241 hasPublicationYear "2005" @default.
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