FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1139525380> ?p ?o ?g. }

• W1139525380 endingPage "360" @default.
• W1139525380 startingPage "347" @default.
• W1139525380 abstract "Abstract Myelin production during brain development requires an increase in membrane protein and lipid production in oligodendrocytes and this primarily occurs in the endoplasmic reticulum (ER), an organelle which initiates the Unfolded Protein Response (UPR) when under stress. We hypothesise that the UPR is activated in white matter tracts during myelination in order to expand the ER capacity of oligodendrocytes. Using early and late stage markers, critical myelination time points were identified by immunohistochemistry in developing rat cerebellum. These were correlated to peaks in ER stress signalling by staining for activated UPR transducers (pIRE1, ATF6 and pPERK) and associated downstream molecules (peIF2α, PDI, GRP78, GRP94, CHOP and calreticulin) in cerebellar tracts III and IV. Gene expression in developing cerebellum was assessed by qPCR. Actively myelinating tracts were shown to have differential expression of pIRE1, PERK and ATF6 as well as UPR targets GRP94, GRP78 and PDI. Activated pIRE1‐positive cells were widespread at P14 and P17 and at significantly higher numbers during myelination than at other stages. Nuclear‐localised ATF6 (indicative of the active transcription factor) peaked at P10, concurrent with the initial phase of myelination. The percentage of cells positive for pPERK was less than 1% at postnatal ages but increased significantly in adult tissue. The downstream targets GRP78, GRP94 and PDI were significantly up‐regulated at P17 compared to P7 and remained significantly elevated in adults. The majority of cells positive for these markers and ATF6 were oligodendrocytes as confirmed by dual‐labelling. Although gene expression in the cerebellum for GRP78, GRP94 and PDI did not change significantly over time, ATF6 and XBP1s both showed significant fold changes between early and late timepoints. This data helps promote understanding of events occurring during developmental myelination and may have implications for the development of reparative treatments in diseases such as multiple sclerosis." @default.
• W1139525380 created "2016-06-24" @default.
• W1139525380 creator A5032558132 @default.
• W1139525380 creator A5067184332 @default.
• W1139525380 creator A5085084133 @default.
• W1139525380 date "2015-08-20" @default.
• W1139525380 modified "2023-09-30" @default.
• W1139525380 title "Differential activation of ER stress pathways in myelinating cerebellar tracts" @default.
• W1139525380 cites W1044743974 @default.
• W1139525380 cites W1527835237 @default.
• W1139525380 cites W1587957817 @default.
• W1139525380 cites W1901457491 @default.
• W1139525380 cites W1940142824 @default.
• W1139525380 cites W1969601520 @default.
• W1139525380 cites W1970090817 @default.
• W1139525380 cites W1973106753 @default.
• W1139525380 cites W1981515291 @default.
• W1139525380 cites W1981551685 @default.
• W1139525380 cites W1992769929 @default.
• W1139525380 cites W1994772574 @default.
• W1139525380 cites W1994813006 @default.
• W1139525380 cites W1999786450 @default.
• W1139525380 cites W2019192392 @default.
• W1139525380 cites W2021112376 @default.
• W1139525380 cites W2031735388 @default.
• W1139525380 cites W2038529477 @default.
• W1139525380 cites W2042675432 @default.
• W1139525380 cites W2043258449 @default.
• W1139525380 cites W2044191383 @default.
• W1139525380 cites W2044550798 @default.
• W1139525380 cites W2047494195 @default.
• W1139525380 cites W2055261197 @default.
• W1139525380 cites W2057135010 @default.
• W1139525380 cites W2058949884 @default.
• W1139525380 cites W2062326815 @default.
• W1139525380 cites W2068319964 @default.
• W1139525380 cites W2074029332 @default.
• W1139525380 cites W2074410745 @default.
• W1139525380 cites W2077026981 @default.
• W1139525380 cites W2079849295 @default.
• W1139525380 cites W2082018654 @default.
• W1139525380 cites W2088350077 @default.
• W1139525380 cites W2101221908 @default.
• W1139525380 cites W2101891297 @default.
• W1139525380 cites W2113483944 @default.
• W1139525380 cites W2127639686 @default.
• W1139525380 cites W2131210945 @default.
• W1139525380 cites W2131632095 @default.
• W1139525380 cites W2136251247 @default.
• W1139525380 cites W2137662702 @default.
• W1139525380 cites W2150440572 @default.
• W1139525380 cites W242692584 @default.
• W1139525380 cites W330374155 @default.
• W1139525380 doi "https://doi.org/10.1016/j.ijdevneu.2015.08.002" @default.
• W1139525380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26297908" @default.
• W1139525380 hasPublicationYear "2015" @default.
• W1139525380 type Work @default.
• W1139525380 sameAs 1139525380 @default.
• W1139525380 citedByCount "21" @default.
• W1139525380 countsByYear W11395253802016 @default.
• W1139525380 countsByYear W11395253802017 @default.
• W1139525380 countsByYear W11395253802018 @default.
• W1139525380 countsByYear W11395253802019 @default.
• W1139525380 countsByYear W11395253802020 @default.
• W1139525380 countsByYear W11395253802021 @default.
• W1139525380 countsByYear W11395253802022 @default.
• W1139525380 countsByYear W11395253802023 @default.
• W1139525380 crossrefType "journal-article" @default.
• W1139525380 hasAuthorship W1139525380A5032558132 @default.
• W1139525380 hasAuthorship W1139525380A5067184332 @default.
• W1139525380 hasAuthorship W1139525380A5085084133 @default.
• W1139525380 hasConcept C126838900 @default.
• W1139525380 hasConcept C134018914 @default.
• W1139525380 hasConcept C139447449 @default.
• W1139525380 hasConcept C143409427 @default.
• W1139525380 hasConcept C158617107 @default.
• W1139525380 hasConcept C2776985911 @default.
• W1139525380 hasConcept C2778609137 @default.
• W1139525380 hasConcept C2778997996 @default.
• W1139525380 hasConcept C2779652256 @default.
• W1139525380 hasConcept C2780876595 @default.
• W1139525380 hasConcept C2781192897 @default.
• W1139525380 hasConcept C529278444 @default.
• W1139525380 hasConcept C71924100 @default.
• W1139525380 hasConcept C86803240 @default.
• W1139525380 hasConcept C95444343 @default.
• W1139525380 hasConceptScore W1139525380C126838900 @default.
• W1139525380 hasConceptScore W1139525380C134018914 @default.
• W1139525380 hasConceptScore W1139525380C139447449 @default.
• W1139525380 hasConceptScore W1139525380C143409427 @default.
• W1139525380 hasConceptScore W1139525380C158617107 @default.
• W1139525380 hasConceptScore W1139525380C2776985911 @default.
• W1139525380 hasConceptScore W1139525380C2778609137 @default.
• W1139525380 hasConceptScore W1139525380C2778997996 @default.
• W1139525380 hasConceptScore W1139525380C2779652256 @default.
• W1139525380 hasConceptScore W1139525380C2780876595 @default.
• W1139525380 hasConceptScore W1139525380C2781192897 @default.
• W1139525380 hasConceptScore W1139525380C529278444 @default.

• next