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- W114066646 startingPage "261" @default.
- W114066646 abstract "The last decade has seen an incredible breakthrough in technologies that allow histones, transcription factors (TFs), and RNA polymerases to be precisely mapped throughout the genome. From this research, it is clear that there is a complex interaction between the chromatin landscape and the general transcriptional machinery and that the dynamic control of this interface is central to gene regulation. However, the chromatin remodeling enzymes and general TFs cannot, on their own, recognize and stably bind to promoter or enhancer regions. Rather, they are recruited to cis regulatory regions through interaction with site-specific DNA binding TFs and/or proteins that recognize epigenetic marks such as methylated cytosines or specifically modified amino acids in histones. These “recruitment” factors are modular in structure, reflecting their ability to interact with the genome via one region of the protein and to simultaneously bind to other regulatory proteins via “effector” domains. In this chapter, we provide examples of common effector domains that can function in transcriptional regulation via their ability to (a) interact with the basal transcriptional machinery and general co-activators, (b) interact with other TFs to allow cooperative binding, and (c) directly or indirectly recruit histone and chromatin modifying enzymes." @default.
- W114066646 created "2016-06-24" @default.
- W114066646 creator A5034247766 @default.
- W114066646 creator A5042896751 @default.
- W114066646 date "2011-01-01" @default.
- W114066646 modified "2023-10-18" @default.
- W114066646 title "Transcription Factor Effector Domains" @default.
- W114066646 cites W1486257535 @default.
- W114066646 cites W1509466986 @default.
- W114066646 cites W1520645352 @default.
- W114066646 cites W1521333964 @default.
- W114066646 cites W1533847046 @default.
- W114066646 cites W1549226038 @default.
- W114066646 cites W1603793127 @default.
- W114066646 cites W1784857457 @default.
- W114066646 cites W1907444180 @default.
- W114066646 cites W1963553964 @default.
- W114066646 cites W1964456768 @default.
- W114066646 cites W1967133987 @default.
- W114066646 cites W1971407164 @default.
- W114066646 cites W1975712471 @default.
- W114066646 cites W1981516673 @default.
- W114066646 cites W1982685209 @default.
- W114066646 cites W1986473194 @default.
- W114066646 cites W1988294855 @default.
- W114066646 cites W1988646837 @default.
- W114066646 cites W1990362235 @default.
- W114066646 cites W1995754186 @default.
- W114066646 cites W1996251138 @default.
- W114066646 cites W1998671864 @default.
- W114066646 cites W1998735636 @default.
- W114066646 cites W2000793078 @default.
- W114066646 cites W2002662963 @default.
- W114066646 cites W2004636267 @default.
- W114066646 cites W2006362317 @default.
- W114066646 cites W2008253949 @default.
- W114066646 cites W2008693523 @default.
- W114066646 cites W2010025781 @default.
- W114066646 cites W2010608530 @default.
- W114066646 cites W2012598468 @default.
- W114066646 cites W2021059897 @default.
- W114066646 cites W2021522009 @default.
- W114066646 cites W2021632119 @default.
- W114066646 cites W2024584416 @default.
- W114066646 cites W2024894759 @default.
- W114066646 cites W2025919590 @default.
- W114066646 cites W2026022568 @default.
- W114066646 cites W2026325417 @default.
- W114066646 cites W2036158314 @default.
- W114066646 cites W2036403623 @default.
- W114066646 cites W2037471080 @default.
- W114066646 cites W2038397261 @default.
- W114066646 cites W2042688292 @default.
- W114066646 cites W2044243386 @default.
- W114066646 cites W2046025970 @default.
- W114066646 cites W2047924159 @default.
- W114066646 cites W2051520501 @default.
- W114066646 cites W2053700118 @default.
- W114066646 cites W2055270107 @default.
- W114066646 cites W2057321383 @default.
- W114066646 cites W2061665609 @default.
- W114066646 cites W2062876308 @default.
- W114066646 cites W2068973408 @default.
- W114066646 cites W2073224213 @default.
- W114066646 cites W2073501968 @default.
- W114066646 cites W2073606168 @default.
- W114066646 cites W2073978750 @default.
- W114066646 cites W2078076994 @default.
- W114066646 cites W2083153667 @default.
- W114066646 cites W2084229225 @default.
- W114066646 cites W2085995080 @default.
- W114066646 cites W2086334687 @default.
- W114066646 cites W2091098061 @default.
- W114066646 cites W2096083625 @default.
- W114066646 cites W2098412979 @default.
- W114066646 cites W2098589211 @default.
- W114066646 cites W2099960599 @default.
- W114066646 cites W2101738855 @default.
- W114066646 cites W2102304447 @default.
- W114066646 cites W2102998538 @default.
- W114066646 cites W2103654209 @default.
- W114066646 cites W2104200252 @default.
- W114066646 cites W2104706866 @default.
- W114066646 cites W2105073128 @default.
- W114066646 cites W2106109160 @default.
- W114066646 cites W2106931266 @default.
- W114066646 cites W2108166446 @default.
- W114066646 cites W2110524124 @default.
- W114066646 cites W2110707963 @default.
- W114066646 cites W2114040881 @default.
- W114066646 cites W2114151755 @default.
- W114066646 cites W2114900293 @default.
- W114066646 cites W2117858386 @default.
- W114066646 cites W2121356384 @default.
- W114066646 cites W2126568240 @default.
- W114066646 cites W2127996002 @default.
- W114066646 cites W2128281293 @default.
- W114066646 cites W2129345907 @default.