FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W114080981> ?p ?o ?g. }

• W114080981 endingPage "484" @default.
• W114080981 startingPage "484" @default.
• W114080981 abstract "Back to table of contents Previous article Next article LETTERFull AccessGABA A Versus GABA B in CatatoniaBrendan T. Carroll M.D.,Christopher Thomas Pharm.D.,Karen C. Tugrul R.N.,Cristonel Coconcea M.D.,Harold W. Goforth M.D.,Brendan T. Carroll M.D.Search for more papers by this author,Christopher Thomas Pharm.D.Search for more papers by this author,Karen C. Tugrul R.N.Search for more papers by this author,Cristonel Coconcea M.D.Search for more papers by this author,Harold W. Goforth M.D.Search for more papers by this author,Published Online:1 Oct 2007https://doi.org/10.1176/jnp.2007.19.4.484AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail SIR: The role of GABA in catatonia has been identified. However, while hypoactivity at GABA A receptor may cause catatonia, increased activity at GABA B may worsen catatonia. 1 We report a patient who suffered from benzodiazepine withdrawal catatonia that could have been worsened by baclofen. A 61-year-old man was treated for anxiety disorder without depressive features with diazepam 5 mg po TID. The patient was also on baclofen 20 mg po TID for cervicalgia.The patient complained of chest pain and was admitted to the telemetry unit for observation. His stay was complicated secondary to refusal of medications, and he consequently suffered benzodiazepine withdrawal delirium accompanied by delusions of being poisoned. Laboratory studies including CBC and chemistry were within normal limits, but vital signs indicated mild autonomic elevations (pulse 110, normal sinus rhythm, blood pressure 165/116) consistent with benzodiazepine withdrawal delirium. A psychiatric consultant noted the presence of catatonic signs including posturing, rigidity, waxy flexibility, negativism, and withdrawal as defined by the refusal of food and oral medications. The Bush-Francis Catatonia Rating Scale score was 20 indicative of moderately severe catatonia. 2 The patient was given an initial dose of lorazepam at 1 mg IV with resolution of his immobility after approximately 1 hour at which time he appeared more agitated with verbal yelling. The patient received haloperidol and ziprasidone during the initial 3 day period to control verbal and physical agitation with mild improvement in overall catatonic signs, but with frequent switching from a psychomotor retarded state to an excited catatonic state. Lorazepam dosed from 3 to 6 mg IV daily was continued during this period to address his benzodiazepine withdrawal delirium as well. Catatonia improved gradually (BFCRS=4), and by the seventh day, the patient showed improvements in orientation, but amnesia to recent events since his illness onset. 2He was seen 1 month later as an outpatient. The patient been discharged on diazepam 5 mg TID but baclofen was not restarted. Four months after this episode he was readmitted for an exacerbation of congestive heart failure. Diazepam was tapered from 5 mg TID to 2.5 mg TID without the return of catatonia or psychosis. This patient’s catatonic presentation appeared mostly likely secondary to benzodiazepine withdrawal delirium and a precipitous decline in GABA A activity after his refusal of po medications. 3 However, the presence of catatonia in this case is interesting because baclofen increases the activity of the GABA B receptor. In this case we found that the addition of baclofen may have upset the balance between GABA A and GABA B activity leading to catatonia that required prolonged treatment with lorazepam, a GABA A promoter for resolution. 4 We feel that this case may illustrate a potentially minor but clinically significant procatatonic role for GABA B activity. 1 , 5University of Cincinnati, and Chillicothe VA Medical Center, Chillicothe, OhioUniversity of Cincinnati, OhioUniversity of Cincinnati, OhioCase Western Reserve University, Cleveland, OhioDuke University Medical Center, Durham, N.C.References1 . Lauterbach E C: Catatonia-like events after valproic acid with risperidone and sertraline. NNBN 1998; 11:157–163Google Scholar2 . Bush G, Fink M, Petrides, et al. Catatonia I: Rating scale and standardized examination. Acta Psychiatr Scand 1996; 93:129–136Google Scholar3 . Rosebush PI, Mazurek MF: Catatonia after benzodiazepine withdrawal. J Clin Psychopharmacol 1996; 16:315–319Google Scholar4 . Northoff G: What catatonia can tell us about “top-down modulation”: a neuropsychiatric hypothesis. Behav Brain Sci 2002; 25:555–604Google Scholar5 . Carroll BT: The GABAa versus GABAb hypothesis of catatonia (letter). Movement Disord 1999; 14:702Google Scholar FiguresReferencesCited byDetailsCited byCatatonia Associated with Intrathecal Baclofen: A Case ReportPsychiatric Annals, Vol. 52, No. 2Progress in sensorimotor neuroscience of schizophrenia spectrum disorders: Lessons learned and future directionsProgress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 111GABAB receptor, clozapine, and catatonia—a complex triad25 September 2020 | Molecular Psychiatry, Vol. 26, No. 7All roads lead to the motor cortex: psychomotor mechanisms and their biochemical modulation in psychiatric disorders17 June 2020 | Molecular Psychiatry, Vol. 26, No. 1Catatonia Associated with Clonazepam WithdrawalPsychiatric Annals, Vol. 50, No. 11A Case of Catatonia in a Man With COVID-19Psychosomatics, Vol. 61, No. 5Catatonia Rating Scales in Patients with Persistent Vegetative StateTaiwanese Journal of Psychiatry, Vol. 34, No. 1Schizophrenia BulletinAn interesting presentation of psychotic catatonia in an elderly patient with alcohol dependenceJournal of Geriatric Mental Health, Vol. 6, No. 2Review of withdrawal catatonia: what does this reveal about clozapine?31 July 2018 | Translational Psychiatry, Vol. 8, No. 1Benzodiazepine treatment of catatoniaFuture Neurology, Vol. 10, No. 5 Volume 19Issue 4 Fall, 2007Pages 484-484 Metrics PDF download History Published online 1 October 2007 Published in print 1 October 2007" @default.
• W114080981 created "2016-06-24" @default.
• W114080981 creator A5015233390 @default.
• W114080981 creator A5058878198 @default.
• W114080981 creator A5062122200 @default.
• W114080981 creator A5072660360 @default.
• W114080981 creator A5074606921 @default.
• W114080981 date "2007-11-01" @default.
• W114080981 modified "2023-09-27" @default.
• W114080981 title "GABAA Versus GABAB in Catatonia" @default.
• W114080981 doi "https://doi.org/10.1176/appi.neuropsych.19.4.484" @default.
• W114080981 hasPublicationYear "2007" @default.
• W114080981 type Work @default.
• W114080981 sameAs 114080981 @default.
• W114080981 citedByCount "4" @default.
• W114080981 countsByYear W1140809812012 @default.
• W114080981 countsByYear W1140809812013 @default.
• W114080981 crossrefType "journal-article" @default.
• W114080981 hasAuthorship W114080981A5015233390 @default.
• W114080981 hasAuthorship W114080981A5058878198 @default.
• W114080981 hasAuthorship W114080981A5062122200 @default.
• W114080981 hasAuthorship W114080981A5072660360 @default.
• W114080981 hasAuthorship W114080981A5074606921 @default.
• W114080981 hasConcept C118552586 @default.
• W114080981 hasConcept C126322002 @default.
• W114080981 hasConcept C15744967 @default.
• W114080981 hasConcept C170493617 @default.
• W114080981 hasConcept C2776412080 @default.
• W114080981 hasConcept C2778173252 @default.
• W114080981 hasConcept C2778941822 @default.
• W114080981 hasConcept C2779706987 @default.
• W114080981 hasConcept C2779753318 @default.
• W114080981 hasConcept C42219234 @default.
• W114080981 hasConcept C558461103 @default.
• W114080981 hasConcept C71924100 @default.
• W114080981 hasConceptScore W114080981C118552586 @default.
• W114080981 hasConceptScore W114080981C126322002 @default.
• W114080981 hasConceptScore W114080981C15744967 @default.
• W114080981 hasConceptScore W114080981C170493617 @default.
• W114080981 hasConceptScore W114080981C2776412080 @default.
• W114080981 hasConceptScore W114080981C2778173252 @default.
• W114080981 hasConceptScore W114080981C2778941822 @default.
• W114080981 hasConceptScore W114080981C2779706987 @default.
• W114080981 hasConceptScore W114080981C2779753318 @default.
• W114080981 hasConceptScore W114080981C42219234 @default.
• W114080981 hasConceptScore W114080981C558461103 @default.
• W114080981 hasConceptScore W114080981C71924100 @default.
• W114080981 hasIssue "4" @default.
• W114080981 hasLocation W1140809811 @default.
• W114080981 hasOpenAccess W114080981 @default.
• W114080981 hasPrimaryLocation W1140809811 @default.
• W114080981 hasRelatedWork W132269087 @default.
• W114080981 hasRelatedWork W2065472193 @default.
• W114080981 hasRelatedWork W2147262029 @default.
• W114080981 hasRelatedWork W2396801341 @default.
• W114080981 hasRelatedWork W2434195530 @default.
• W114080981 hasRelatedWork W2759325487 @default.
• W114080981 hasRelatedWork W4283075075 @default.
• W114080981 hasRelatedWork W4313191280 @default.
• W114080981 hasRelatedWork W4313304417 @default.
• W114080981 hasRelatedWork W86223993 @default.
• W114080981 hasVolume "19" @default.
• W114080981 isParatext "false" @default.
• W114080981 isRetracted "false" @default.
• W114080981 magId "114080981" @default.
• W114080981 workType "article" @default.