FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W114098355> ?p ?o ?g. }

• W114098355 endingPage "282" @default.
• W114098355 startingPage "221" @default.
• W114098355 abstract "Most aspects of mammalian function display circadian rhythms driven by an endogenous clock. The circadian clock is operated by genes and comprises a central clock in the brain that responds to environmental cues and controls subordinate clocks in peripheral tissues via circadian output pathways. The central and peripheral clocks coordinately generate rhythmic gene expression in a tissue-specific manner in vivo to couple diverse physiological and behavioral processes to periodic changes in the environment. However, with the industrialization of the world, activities that disrupt endogenous homeostasis with external circadian cues have increased. This change in lifestyle has been linked to an increased risk of diseases in all aspects of human health, including cancer. Studies in humans and animal models have revealed that cancer development in vivo is closely associated with the loss of circadian homeostasis in energy balance, immune function, and aging, which are supported by cellular functions important for tumor suppression including cell proliferation, senescence, metabolism, and DNA damage response. The clock controls these cellular functions both locally in cells of peripheral tissues and at the organismal level via extracellular signaling. Thus, the hierarchical mammalian circadian clock provides a unique system to study carcinogenesis as a deregulated physiological process in vivo. The asynchrony between host and malignant tissues in cell proliferation and metabolism also provides new and exciting options for novel anticancer therapies." @default.
• W114098355 created "2016-06-24" @default.
• W114098355 creator A5026936750 @default.
• W114098355 creator A5071468365 @default.
• W114098355 date "2013-01-01" @default.
• W114098355 modified "2023-10-10" @default.
• W114098355 title "The Circadian Clock in Cancer Development and Therapy" @default.
• W114098355 cites W113396487 @default.
• W114098355 cites W125070395 @default.
• W114098355 cites W1481045036 @default.
• W114098355 cites W1483130700 @default.
• W114098355 cites W1486783710 @default.
• W114098355 cites W150521681 @default.
• W114098355 cites W1506436252 @default.
• W114098355 cites W1512072225 @default.
• W114098355 cites W1519199639 @default.
• W114098355 cites W1522804078 @default.
• W114098355 cites W1525288721 @default.
• W114098355 cites W1529003705 @default.
• W114098355 cites W1530371171 @default.
• W114098355 cites W1554815317 @default.
• W114098355 cites W1565455383 @default.
• W114098355 cites W1575816236 @default.
• W114098355 cites W1593300855 @default.
• W114098355 cites W1602542637 @default.
• W114098355 cites W1604211023 @default.
• W114098355 cites W1629086938 @default.
• W114098355 cites W1642873092 @default.
• W114098355 cites W1646267184 @default.
• W114098355 cites W1656708631 @default.
• W114098355 cites W1667092336 @default.
• W114098355 cites W1744822607 @default.
• W114098355 cites W1792935080 @default.
• W114098355 cites W180197682 @default.
• W114098355 cites W184525533 @default.
• W114098355 cites W1879241542 @default.
• W114098355 cites W1892385952 @default.
• W114098355 cites W1903413446 @default.
• W114098355 cites W1920308054 @default.
• W114098355 cites W1933267068 @default.
• W114098355 cites W1946383112 @default.
• W114098355 cites W1951489781 @default.
• W114098355 cites W1964544156 @default.
• W114098355 cites W1965009601 @default.
• W114098355 cites W1965037168 @default.
• W114098355 cites W1965239527 @default.
• W114098355 cites W1965310675 @default.
• W114098355 cites W1966045571 @default.
• W114098355 cites W1966782228 @default.
• W114098355 cites W1968972230 @default.
• W114098355 cites W1969631412 @default.
• W114098355 cites W1970559976 @default.
• W114098355 cites W1970657971 @default.
• W114098355 cites W1970924670 @default.
• W114098355 cites W1971040855 @default.
• W114098355 cites W1971085650 @default.
• W114098355 cites W1971883897 @default.
• W114098355 cites W1973099196 @default.
• W114098355 cites W1973655938 @default.
• W114098355 cites W1975150591 @default.
• W114098355 cites W1975191711 @default.
• W114098355 cites W1975701262 @default.
• W114098355 cites W1975787992 @default.
• W114098355 cites W1975854213 @default.
• W114098355 cites W1976540475 @default.
• W114098355 cites W1976874039 @default.
• W114098355 cites W1977059470 @default.
• W114098355 cites W1977518394 @default.
• W114098355 cites W1977589396 @default.
• W114098355 cites W1979194439 @default.
• W114098355 cites W1979895785 @default.
• W114098355 cites W1981463574 @default.
• W114098355 cites W1981557521 @default.
• W114098355 cites W1981782684 @default.
• W114098355 cites W1982216464 @default.
• W114098355 cites W1983034374 @default.
• W114098355 cites W1983687580 @default.
• W114098355 cites W1984945725 @default.
• W114098355 cites W1984954393 @default.
• W114098355 cites W1985105677 @default.
• W114098355 cites W1985110168 @default.
• W114098355 cites W1985299033 @default.
• W114098355 cites W1985781201 @default.
• W114098355 cites W1986599980 @default.
• W114098355 cites W1986738450 @default.
• W114098355 cites W1986784668 @default.
• W114098355 cites W1986837147 @default.
• W114098355 cites W1987216302 @default.
• W114098355 cites W1987938190 @default.
• W114098355 cites W1988097700 @default.
• W114098355 cites W1988428451 @default.
• W114098355 cites W1988831545 @default.
• W114098355 cites W1989737168 @default.
• W114098355 cites W1990192893 @default.
• W114098355 cites W1990777401 @default.
• W114098355 cites W1990821337 @default.
• W114098355 cites W1991198879 @default.
• W114098355 cites W1991333402 @default.

• next