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- W114194911 abstract "To investigate the state of endothelial cell activation in vasculitis, scleroderma, and systemic lupus erythematosus (SLE).We used a sandwich ELISA to quantitate a soluble form of endothelial leukocyte adhesion molecule-1 (sELAM) in serum.sELAM was detected in serum from healthy individuals (mean 0.92 ng/ml). Levels were significantly higher in patients with giant cell arteritis (mean 2.04 ng/ml), polyarteritis nodosa (mean 2.08 ng/ml), scleroderma (mean 2.27 ng/ml), and SLE (mean 3.93 ng/ml). Elevated values were present in patients with both active and inactive disease. sELAM levels of > 3 ng/ml identified most patients with recent onset or active disease.Our findings may reflect a low degree of endothelial cell activation in healthy persons that is increased in inflammatory diseases involving blood vessels. Elevated serum sELAM levels may reflect ongoing inflammatory processes in these diseases." @default.
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- W114194911 date "1993-05-01" @default.
- W114194911 modified "2023-09-26" @default.
- W114194911 title "Serum ELAM-1 is increased in vasculitis, scleroderma, and systemic lupus erythematosus." @default.
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