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- W114383725 abstract "Behavioral and motor dysfunction are associated with airborne manganese (Mn) exposures. We have previously found that iron deficiency enhances olfactory Mn uptake. We further investigated the effect of iron deficiency on brain distribution of intranasally-instilled manganese using MRI. Weanling rats were fed either control chow (220 ppm Fe) or iron-deficient diet (5 ppm Fe) for 4 weeks. MnCl2 (30-60 mg/kg) or water (control) was repeatedly instilled through the right nostril for 1-3 weeks and T1-weighted MRI for brain Mn was obtained. Most brain areas accumulated more Mn in iron-deficient rats compared with control rats, but with no preferential regional distribution. Normalized signal intensities indicated olfactory Mn uptake was doubled in iron-deficient rats. Microdialysis was used to determine dopamine concentrations in the striatum (AP+0.07, LR-0.28, DV-0.38 cm) in a similar cohort of rats. Neither iron status nor intra-nasal Mn instillation altered potassium-evoked striatal dopamine levels, suggesting that neurological effects associated with Mn exposure do not result from dopamine depletion. Supported by NIH grant ES014638." @default.
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- W114383725 date "2009-04-01" @default.
- W114383725 modified "2023-10-12" @default.
- W114383725 title "Effect of iron status on olfactory uptake of manganese and its distribution in the brain" @default.
- W114383725 doi "https://doi.org/10.1096/fasebj.23.1_supplement.921.8" @default.
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