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- W114425580 abstract "502 Objectives: Several staging systems have been used for multiple myeloma (MM). Durie/Salmon staging system (DSS) is based on laboratory findings and the number of lesions by imaging study, but new international stating system (ISS) on prognostic factors; Serum beta2-microglobulin (Sβ2M), and serum albumin. The aim of this study was to evaluate the clinical usefulness of 18F-FDG PET/CT (PET/CT) for initial stating of MM. Methods: Fifteen patients who had newly diagnosed MM (M: F=6:9, median age=59 y) were prospectively studied. We intended to recommend following PET/CT extent stages system for MM involvement: stage I, 3 ≥ number of bone with FDG uptake; stage II, neither stage I nor III; stage III, diffuse FDG uptakes in whole vertebrae and another marrow space. We analyzed following PET/CT parameters; PET/CT extent stages, the number of hypermetabolic lesion (HML), total functional volume of HML with cut off value of SUV of 2.5, maximum SUV of HML, visual grades comparing with liver uptake (the degree of FDG uptake for totally involved lesions; grade 1, ≤ liver; grade 2, ≥ liver; grade 3, > liver; grade 4, >> liver) SUV of liver. We compared these PET/CT parameters with DSS or ISS and other prognosis related serologic markers. Results: All of 15 patients was stage III by DSS. Being based on ISS, there were stage I of 8, stage II of 2, and the stage III of 5. There was a positive correlation PET/CT extent stages (rho=0.558, p" @default.
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- W114425580 date "2007-05-01" @default.
- W114425580 modified "2023-09-23" @default.
- W114425580 title "The role of 18F-FDG-PET/CT for staging in multiple myeloma" @default.
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