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- W114482397 abstract "The phenothiazines are, in vitro , powerful metabolic blocking agents and they act in the respiratory chain at the flavoprotein level. However, it is doubtful if this is their main action in vivo , since the brain levels of ATP and creatine phosphate are relatively high after treatment with chlorpromazine whereas the reverse would be expected if the drug competed with flavine adenine dinucleotide, as has been suggested. In low doses chlorpromazine has been shown to accelerate the turnover rate of phospholipids in vivo. This effect is specific for the phospholipids of the brain and it is of particular interest since the phenothiazines are concentrated in the mitochondrial membranes of the nerve cells, which are rich in phospholipids. The phenothiazines have been shown to interfere with the transport of many metabolites in the brain. However, this action is not specific for the brain and, since it is shown also by other surface-active substances, it is difficult to relate this effect directly to the highly specific pharmacological action on the central nervous system. The psychotropically active phenothiazines, however, all have a central sympatholytic action: it has been suggested that this may be due to their interfering with the transport of biogenic amines from the point of synthesis to the storage sites or to the receptor sites in the brain." @default.
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- W114482397 date "1965-01-01" @default.
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- W114482397 title "MODE OF ACTION OF THE PHENOTHIAZINES" @default.
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- W114482397 doi "https://doi.org/10.1016/b978-0-08-011195-7.50012-5" @default.
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