Matches in SemOpenAlex for { <https://semopenalex.org/work/W1144906992> ?p ?o ?g. }
- W1144906992 endingPage "35" @default.
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- W1144906992 abstract "Aquaporin (AQP) water and solute channels have basic physiological functions throughout the human body. AQP-facilitated water permeability across cell membranes is required for rapid reabsorption of water from pre-urine in the kidneys and for sustained near isosmolar water fluxes e.g. in the brain, eyes, inner ear, and lungs. Cellular water permeability is further connected to cell motility. AQPs of the aquaglyceroporin subfamily are necessary for lipid degradation in adipocytes and glycerol uptake into the liver, as well as for skin moistening. Modulation of AQP function is desirable in several pathophysiological situations, such as nephrogenic diabetes insipidus, Sjögren's syndrome, Menière's disease, heart failure, or tumors to name a few. Attempts to design or to find effective small molecule AQP inhibitors have yielded only a few hits. Challenges reside in the high copy number of AQP proteins in the cell membranes, and spatial restrictions in the protein structure. This review gives an overview on selected physiological and pathophysiological conditions in which modulation of AQP functions appears beneficial and discusses first achievements in the search of drug-like AQP inhibitors." @default.
- W1144906992 created "2016-06-24" @default.
- W1144906992 creator A5005788321 @default.
- W1144906992 creator A5022772549 @default.
- W1144906992 creator A5038422491 @default.
- W1144906992 creator A5075251955 @default.
- W1144906992 date "2015-11-01" @default.
- W1144906992 modified "2023-09-30" @default.
- W1144906992 title "Challenges and achievements in the therapeutic modulation of aquaporin functionality" @default.
- W1144906992 cites W136300496 @default.
- W1144906992 cites W1479762169 @default.
- W1144906992 cites W1492555480 @default.
- W1144906992 cites W1495656315 @default.
- W1144906992 cites W1498453842 @default.
- W1144906992 cites W1527760132 @default.
- W1144906992 cites W1531397157 @default.
- W1144906992 cites W1535419310 @default.
- W1144906992 cites W1539407279 @default.
- W1144906992 cites W1559236087 @default.
- W1144906992 cites W1580434367 @default.
- W1144906992 cites W1591974057 @default.
- W1144906992 cites W1607563537 @default.
- W1144906992 cites W1835620973 @default.
- W1144906992 cites W1852199856 @default.
- W1144906992 cites W1933970956 @default.
- W1144906992 cites W1940008989 @default.
- W1144906992 cites W1947778485 @default.
- W1144906992 cites W1967265143 @default.
- W1144906992 cites W1968510168 @default.
- W1144906992 cites W1969463227 @default.
- W1144906992 cites W1970084867 @default.
- W1144906992 cites W1971909283 @default.
- W1144906992 cites W1971933116 @default.
- W1144906992 cites W1974228630 @default.
- W1144906992 cites W1974587361 @default.
- W1144906992 cites W1975517087 @default.
- W1144906992 cites W1975652298 @default.
- W1144906992 cites W1977396044 @default.
- W1144906992 cites W1978249133 @default.
- W1144906992 cites W1979280816 @default.
- W1144906992 cites W1980044885 @default.
- W1144906992 cites W1982532159 @default.
- W1144906992 cites W1983746433 @default.
- W1144906992 cites W1984284559 @default.
- W1144906992 cites W1988344652 @default.
- W1144906992 cites W1991803772 @default.
- W1144906992 cites W1993064394 @default.
- W1144906992 cites W1994179682 @default.
- W1144906992 cites W1994698746 @default.
- W1144906992 cites W1995178724 @default.
- W1144906992 cites W1995627314 @default.
- W1144906992 cites W1996387393 @default.
- W1144906992 cites W1997329885 @default.
- W1144906992 cites W1997448861 @default.
- W1144906992 cites W1997685015 @default.
- W1144906992 cites W1998548799 @default.
- W1144906992 cites W1999758893 @default.
- W1144906992 cites W2000142729 @default.
- W1144906992 cites W2001610592 @default.
- W1144906992 cites W2002076163 @default.
- W1144906992 cites W2002821884 @default.
- W1144906992 cites W2003470142 @default.
- W1144906992 cites W2005664680 @default.
- W1144906992 cites W2006823250 @default.
- W1144906992 cites W2007202521 @default.
- W1144906992 cites W2008726342 @default.
- W1144906992 cites W2009703891 @default.
- W1144906992 cites W2011991034 @default.
- W1144906992 cites W2013320855 @default.
- W1144906992 cites W2014549711 @default.
- W1144906992 cites W2014749038 @default.
- W1144906992 cites W2016069829 @default.
- W1144906992 cites W2017564519 @default.
- W1144906992 cites W2020099135 @default.
- W1144906992 cites W2020839799 @default.
- W1144906992 cites W2021512471 @default.
- W1144906992 cites W2022553472 @default.
- W1144906992 cites W2023342339 @default.
- W1144906992 cites W2023601465 @default.
- W1144906992 cites W2024695156 @default.
- W1144906992 cites W2026765480 @default.
- W1144906992 cites W2028075573 @default.
- W1144906992 cites W2029335938 @default.
- W1144906992 cites W2030112038 @default.
- W1144906992 cites W2031275782 @default.
- W1144906992 cites W2032482731 @default.
- W1144906992 cites W2032613498 @default.
- W1144906992 cites W2032789959 @default.
- W1144906992 cites W2033503608 @default.
- W1144906992 cites W2034998098 @default.
- W1144906992 cites W2035945165 @default.
- W1144906992 cites W2040733706 @default.
- W1144906992 cites W2041178268 @default.
- W1144906992 cites W2042282096 @default.
- W1144906992 cites W2042458891 @default.
- W1144906992 cites W2043266591 @default.
- W1144906992 cites W2044714247 @default.
- W1144906992 cites W2045459991 @default.