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• W1145011015 abstract "Frailty is a still-evolving concept of a complex phenomenon. There are several algorithms and strategies for assessing frailty syndrome, but currently, no universally accepted definition or measurement protocol has been determined. Consequently, the biological cause(s) of frailty are also poorly defined. Much circumstantial experimental data point to the dysregulation of several key physiological systems, including the neuroendocrine, musculoskeletal, metabolic and immune/inflammatory systems, resulting from alterations in functional reserves. Immune dysregulation and inflammation as causes of frailty have gained some support from the results of longitudinal studies, but a true causal relationship has not been established. This chapter will describe the immune/inflammatory alterations found in frailty and their putative causal relationships with this state." @default.
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• W1145011015 date "2015-01-01" @default.
• W1145011015 modified "2023-10-18" @default.
• W1145011015 title "Frailty, Inflammation and Immunosenescence" @default.
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• W1145011015 doi "https://doi.org/10.1159/000381134" @default.
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