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- W1145226475 endingPage "227" @default.
- W1145226475 startingPage "213" @default.
- W1145226475 abstract "Lipoxygenases are enzymes that catalyze the hydroperoxidation of polyunsaturated fatty acids, esters, alcohols, and others containing a cis-cis-1,4-pentadiene system; the products contain 1-hydroperoxy-2,4-trans, cispentadiene fragments. The enzymes belong to the class known as dioxygenases that characteristically incorporate two atoms of molecular oxygen into a substrate. It was found in 1974 that Guinea pig lung and spleen homogenates produced at least ten times as much 12-hydroxyeicosatetraenoic acid (HETE) when incubated with AA as did homogenates of kidney, stomach, liver, heart, and whole blood. The term arachidonate lipoxygenase was coined shortly hereafter when the enzyme isolated from platelets of various mammals displayed higher conversion rates for AA than for a variety of other fatty acids containing the cis-cis-1,4-pentadiene fragment. Dihydroxyeicosatetraenoic acids (di-HETEs) were isolated after the incubation of suspensions of rabbit peritoneal polymorphonuclear leucocytes (PMNL) with AA and the unstable (leukotriene A4) was proposed as the reactive intermediate. In addition to human platelets, guinea pig lung and spleen homogenates, rabbit PMNL, human neutrophil, and rat RBL-1 cells, other tissues have been reported to display lipoxygenase activity against a variety of substrates. Researchers examined a large list of flavonoids for the inhibition of lipoxygenase from soybean, from rat lung, and spleen and for the inhibition of PG synthetase from rat renal medulla. A comparison of 27 and 1,5-dihydroxynaphthalene, using plant and rat lipoxygenases, shows almost identical inhibition properties, adding evidence that most soybean lipoxygenase inhibitors inhibit animal lipoxygenase as well." @default.
- W1145226475 created "2016-06-24" @default.
- W1145226475 creator A5029195556 @default.
- W1145226475 creator A5074111560 @default.
- W1145226475 date "1981-01-01" @default.
- W1145226475 modified "2023-10-02" @default.
- W1145226475 title "Chapter 20. Arachidonate Lipoxygenase" @default.
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