Matches in SemOpenAlex for { <https://semopenalex.org/work/W1145543624> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1145543624 abstract "Phagocytes are among the most dynamic cells in the body. Within seconds of exposure to a chemotactic peptide, they are able to convert from a rounded symmetric shape to a polarized morphology. Actin polymerization not only drives the motility of all mammalian nonmuscle cells, but also provides the propulsive force for the movement of intracellular bacteria including Listeria, Shigella, and Rickettsia, as well as the poxvirus vaccinia. Actin is the most abundant protein in the cytoplasm of phagocytes, representing 10 to 20% of the total cytoplasmic protein. The cytoplasm of phagocytes contains high concentrations of unpolymerized actin that exceed by several orders of magnitude the macroscopic critical concentration of purified actin. The factor primarily responsible for preventing actin monomer assembly into filaments is the 5-kDa polypeptide known as thymosin β4 (Tβ4). This small protein binds to a single actin monomer to form a 1:1, or binary, complex. High rates of actin assembly are required to produce the rapid changes in shape observed during phagocyte amoeboid movement. Adherence receptors contain high concentrations of actin filaments and are linked to the actin cytoskeleton by ezrin, radixin, and moesin (the ERM proteins). Proteins that bind to the barbed ends of actin filaments have a profound effect on filament growth. The barbed end has a high affinity for actin monomers and in combination with profilin can readily compete with Tβ4 for sequestered ATP-actin monomers." @default.
- W1145543624 created "2016-06-24" @default.
- W1145543624 creator A5022650716 @default.
- W1145543624 date "2014-04-30" @default.
- W1145543624 modified "2023-09-25" @default.
- W1145543624 title "Actin-Based Motility in Professional Phagocytes" @default.
- W1145543624 cites W1965964686 @default.
- W1145543624 cites W1969859008 @default.
- W1145543624 cites W1970072446 @default.
- W1145543624 cites W1972779128 @default.
- W1145543624 cites W1977019885 @default.
- W1145543624 cites W1995944608 @default.
- W1145543624 cites W1997481960 @default.
- W1145543624 cites W2006966544 @default.
- W1145543624 cites W2031429450 @default.
- W1145543624 cites W2032006582 @default.
- W1145543624 cites W2062325757 @default.
- W1145543624 cites W2063116489 @default.
- W1145543624 cites W2088635839 @default.
- W1145543624 cites W2096136044 @default.
- W1145543624 cites W2098278940 @default.
- W1145543624 cites W2109579264 @default.
- W1145543624 cites W2119836020 @default.
- W1145543624 cites W2123944878 @default.
- W1145543624 cites W2128736294 @default.
- W1145543624 cites W2130935296 @default.
- W1145543624 cites W2140040046 @default.
- W1145543624 cites W84272969 @default.
- W1145543624 doi "https://doi.org/10.1128/9781555816650.ch15" @default.
- W1145543624 hasPublicationYear "2014" @default.
- W1145543624 type Work @default.
- W1145543624 sameAs 1145543624 @default.
- W1145543624 citedByCount "0" @default.
- W1145543624 crossrefType "book-chapter" @default.
- W1145543624 hasAuthorship W1145543624A5022650716 @default.
- W1145543624 hasConcept C125705527 @default.
- W1145543624 hasConcept C130861313 @default.
- W1145543624 hasConcept C142669718 @default.
- W1145543624 hasConcept C1491633281 @default.
- W1145543624 hasConcept C160448771 @default.
- W1145543624 hasConcept C189040839 @default.
- W1145543624 hasConcept C190062978 @default.
- W1145543624 hasConcept C203253989 @default.
- W1145543624 hasConcept C2777700362 @default.
- W1145543624 hasConcept C2993400109 @default.
- W1145543624 hasConcept C3620293 @default.
- W1145543624 hasConcept C55493867 @default.
- W1145543624 hasConcept C59999672 @default.
- W1145543624 hasConcept C86803240 @default.
- W1145543624 hasConcept C95444343 @default.
- W1145543624 hasConceptScore W1145543624C125705527 @default.
- W1145543624 hasConceptScore W1145543624C130861313 @default.
- W1145543624 hasConceptScore W1145543624C142669718 @default.
- W1145543624 hasConceptScore W1145543624C1491633281 @default.
- W1145543624 hasConceptScore W1145543624C160448771 @default.
- W1145543624 hasConceptScore W1145543624C189040839 @default.
- W1145543624 hasConceptScore W1145543624C190062978 @default.
- W1145543624 hasConceptScore W1145543624C203253989 @default.
- W1145543624 hasConceptScore W1145543624C2777700362 @default.
- W1145543624 hasConceptScore W1145543624C2993400109 @default.
- W1145543624 hasConceptScore W1145543624C3620293 @default.
- W1145543624 hasConceptScore W1145543624C55493867 @default.
- W1145543624 hasConceptScore W1145543624C59999672 @default.
- W1145543624 hasConceptScore W1145543624C86803240 @default.
- W1145543624 hasConceptScore W1145543624C95444343 @default.
- W1145543624 hasLocation W11455436241 @default.
- W1145543624 hasOpenAccess W1145543624 @default.
- W1145543624 hasPrimaryLocation W11455436241 @default.
- W1145543624 hasRelatedWork W112372703 @default.
- W1145543624 hasRelatedWork W113641295 @default.
- W1145543624 hasRelatedWork W1969950216 @default.
- W1145543624 hasRelatedWork W1994716561 @default.
- W1145543624 hasRelatedWork W2043722146 @default.
- W1145543624 hasRelatedWork W2053635924 @default.
- W1145543624 hasRelatedWork W2058597230 @default.
- W1145543624 hasRelatedWork W2073005565 @default.
- W1145543624 hasRelatedWork W2090712867 @default.
- W1145543624 hasRelatedWork W2094521496 @default.
- W1145543624 hasRelatedWork W2104980653 @default.
- W1145543624 hasRelatedWork W2106334412 @default.
- W1145543624 hasRelatedWork W2137177627 @default.
- W1145543624 hasRelatedWork W2141578479 @default.
- W1145543624 hasRelatedWork W2415958158 @default.
- W1145543624 hasRelatedWork W2549172605 @default.
- W1145543624 hasRelatedWork W2741463872 @default.
- W1145543624 hasRelatedWork W2883904245 @default.
- W1145543624 hasRelatedWork W46378961 @default.
- W1145543624 hasRelatedWork W657023581 @default.
- W1145543624 isParatext "false" @default.
- W1145543624 isRetracted "false" @default.
- W1145543624 magId "1145543624" @default.
- W1145543624 workType "book-chapter" @default.