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- W1145854561 abstract "Publisher Summary This chapter discusses the assay of effect of (2'-5')-Oligoadenylate on Macrophages. The main component of the (2'-5')-Oligo (A) family is pppA2'ps'A2'ps'A abbreviated (2'-5')P 3 A 3 . It is produced by the (2'-5')-oligo(A) synthetase from interferon-induced cells or from reticulocytes. The effect of interferon on immune cells is an important aspect of its action. (2'-5')-Oligo (A) can regulate the action of natural killer cells and macrophages. (2'-5')P 3 A 3 enhances the activity of macrophages from different species (mice, rats, guinea pigs, rabbits, and human) and antagonizes the inhibitory effect of α-fetoprotein on macrophages. This action of (2'-5') P 3 A 3 on the macrophages appears to be mediated by a receptor. Measuring the direct effect of (2'-5') P 3 A 3 on macrophages, as described in the chapter, without the use CaCI 2 or other agents can provide some information for the possible effect of (2'-5')P 3 A 3 and its derivatives on the immune system, which may be useful clinically." @default.
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- W1145854561 date "1986-01-01" @default.
- W1145854561 modified "2023-10-14" @default.
- W1145854561 title "[88] Assay of effect of (2′-5′)-oligoadenylate on macrophages" @default.
- W1145854561 cites W2003247172 @default.
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- W1145854561 doi "https://doi.org/10.1016/0076-6879(86)19090-2" @default.
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