Matches in SemOpenAlex for { <https://semopenalex.org/work/W1145947982> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1145947982 abstract "BACKGROUND: Cardiac allograft vasculopathy (CAV) accounts for significant mortality after heart transplant (HT). The identification of molecular pathways involved in CAV may provide targets for preventive therapies and development of risk markers. METHOD: Gene expression profiling and transcriptome analysis using Illumina HiSeq 2000, was performed in 23 HT recipients, 12 with ISHLT grade 3 CAV and 11 without CAV matched on age, gender, and HT duration. Fastqc, Tophat, Samtools, and CuffDiff were utilized for quality control of raw reads, mapping short reads to reference genomes and testing differential expression between healthy subjects and HT recipients. Ingenuity pathway analysis (IPA) was performed to identify molecular pathways demonstrating differential expression. RESULT: Mean age was 54.6yrs, mean duration of transplant 8.1yrs, 69% were men, and etiology of HT was ischemic in 47.8%. IPA analysis revealed abnormalities in the following pathways: disease and biological functions, molecular and cellular functions, catonical pathways and toxicity. When cardiovascular pathways were evaluated, CAV was associated with differential expression in genes involved in cardiac arteriopathy, inflammation, fibrosis, heart failure, and arrhythmia. (Table 1) Conclusion: Genes associated with inflammation, arteriopathy, fibrosis, heart failure, and arrhythmias are differentially expressed in CAV. Longitudinal evaluation is required to determine the relationship of these genes and pathways to risk and development of CAV and their response to specific therapies." @default.
- W1145947982 created "2016-06-24" @default.
- W1145947982 creator A5028789311 @default.
- W1145947982 creator A5042973046 @default.
- W1145947982 creator A5048636771 @default.
- W1145947982 creator A5059093059 @default.
- W1145947982 creator A5082800331 @default.
- W1145947982 creator A5085683956 @default.
- W1145947982 date "2014-11-25" @default.
- W1145947982 modified "2023-09-25" @default.
- W1145947982 title "Abstract 20236: Differential Expression of Genes Associated With Cardiovascular Disease in Cardiac Allograft Vasculopathy" @default.
- W1145947982 hasPublicationYear "2014" @default.
- W1145947982 type Work @default.
- W1145947982 sameAs 1145947982 @default.
- W1145947982 citedByCount "0" @default.
- W1145947982 crossrefType "journal-article" @default.
- W1145947982 hasAuthorship W1145947982A5028789311 @default.
- W1145947982 hasAuthorship W1145947982A5042973046 @default.
- W1145947982 hasAuthorship W1145947982A5048636771 @default.
- W1145947982 hasAuthorship W1145947982A5059093059 @default.
- W1145947982 hasAuthorship W1145947982A5082800331 @default.
- W1145947982 hasAuthorship W1145947982A5085683956 @default.
- W1145947982 hasConcept C104317684 @default.
- W1145947982 hasConcept C126322002 @default.
- W1145947982 hasConcept C142724271 @default.
- W1145947982 hasConcept C150194340 @default.
- W1145947982 hasConcept C162317418 @default.
- W1145947982 hasConcept C18431079 @default.
- W1145947982 hasConcept C2776914184 @default.
- W1145947982 hasConcept C2778198053 @default.
- W1145947982 hasConcept C2779134260 @default.
- W1145947982 hasConcept C2780559512 @default.
- W1145947982 hasConcept C54355233 @default.
- W1145947982 hasConcept C60644358 @default.
- W1145947982 hasConcept C69991583 @default.
- W1145947982 hasConcept C71924100 @default.
- W1145947982 hasConcept C86803240 @default.
- W1145947982 hasConceptScore W1145947982C104317684 @default.
- W1145947982 hasConceptScore W1145947982C126322002 @default.
- W1145947982 hasConceptScore W1145947982C142724271 @default.
- W1145947982 hasConceptScore W1145947982C150194340 @default.
- W1145947982 hasConceptScore W1145947982C162317418 @default.
- W1145947982 hasConceptScore W1145947982C18431079 @default.
- W1145947982 hasConceptScore W1145947982C2776914184 @default.
- W1145947982 hasConceptScore W1145947982C2778198053 @default.
- W1145947982 hasConceptScore W1145947982C2779134260 @default.
- W1145947982 hasConceptScore W1145947982C2780559512 @default.
- W1145947982 hasConceptScore W1145947982C54355233 @default.
- W1145947982 hasConceptScore W1145947982C60644358 @default.
- W1145947982 hasConceptScore W1145947982C69991583 @default.
- W1145947982 hasConceptScore W1145947982C71924100 @default.
- W1145947982 hasConceptScore W1145947982C86803240 @default.
- W1145947982 hasLocation W11459479821 @default.
- W1145947982 hasOpenAccess W1145947982 @default.
- W1145947982 hasPrimaryLocation W11459479821 @default.
- W1145947982 hasRelatedWork W2019284634 @default.
- W1145947982 hasRelatedWork W2039981498 @default.
- W1145947982 hasRelatedWork W2074578226 @default.
- W1145947982 hasRelatedWork W2088534117 @default.
- W1145947982 hasRelatedWork W2139367613 @default.
- W1145947982 hasRelatedWork W2159764489 @default.
- W1145947982 hasRelatedWork W2229624815 @default.
- W1145947982 hasRelatedWork W2284048622 @default.
- W1145947982 hasRelatedWork W2360025407 @default.
- W1145947982 hasRelatedWork W2387172169 @default.
- W1145947982 hasRelatedWork W2521429910 @default.
- W1145947982 hasRelatedWork W2611645867 @default.
- W1145947982 hasRelatedWork W3005783703 @default.
- W1145947982 hasRelatedWork W3008702450 @default.
- W1145947982 hasRelatedWork W3127790445 @default.
- W1145947982 hasRelatedWork W3136274202 @default.
- W1145947982 hasRelatedWork W3138551199 @default.
- W1145947982 hasRelatedWork W3139013720 @default.
- W1145947982 hasRelatedWork W3178277634 @default.
- W1145947982 hasRelatedWork W3191428344 @default.
- W1145947982 hasVolume "130" @default.
- W1145947982 isParatext "false" @default.
- W1145947982 isRetracted "false" @default.
- W1145947982 magId "1145947982" @default.
- W1145947982 workType "article" @default.