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- W1146069877 abstract "Publisher SummaryAdhesion of cells to one another and to the extracellular matrix is crucial to embryonic development, maintenance of tissue architecture, the inflammatory response, tumor metastasis, and wound healing. This chapter explains the current understanding of the cell adhesion molecule (CAM) families and highlights their role in lung structure and the inflammatory response as observed in asthma and chronic obstructive pulmonary disease (COPD). The CAMs are grouped into distinct families based on their molecular structure: integrins, the immunoglobulin supergene family, selectins, cadherins, and other proteoglycans. CAMs potentially mediate cell migration, leukocyte activation, and interstitial cell–cell interactions. Identification of these complex and interrelated functions leads to an increasing need for additional studies to further define the in vivo function of the known CAMs in the airway. The ultimate goal of current adhesion-molecule research is to elucidate the mechanisms that regulate the inflammatory response and explain the specific role of adhesion molecules in airway inflammation." @default.
- W1146069877 created "2016-06-24" @default.
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- W1146069877 date "2002-01-01" @default.
- W1146069877 modified "2023-09-23" @default.
- W1146069877 title "Cell Adhesion Molecules" @default.
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- W1146069877 doi "https://doi.org/10.1016/b978-012079028-9/50096-x" @default.
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