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• W114612069 startingPage "427" @default.
• W114612069 abstract "Retinal ganglion cells (RGC) are the projection neurons of the eye. The RGC is the primary cell type injured in a variety of diseases of the optic nerve, including glaucoma and optic neuritis. The most well-established extrinsic signal of RGC survival and axonal outgrowth is the neurotrophin brain-derived neurotrophic factor. An immunopurification system has been adapted in order to filter large enough quantities of RGCs from the mixed population of retinal neurons in order to perform high-throughput screening in a 96-well format. Using this assay, the screening of a combinatorial chemical library for compounds with a similar effect to brain-derived neurotrophic factor may be preformed. Follow-up validation studies are performed by evaluating for a dose-response relationship." @default.
• W114612069 created "2016-06-24" @default.
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• W114612069 date "2006-09-20" @default.
• W114612069 modified "2023-09-25" @default.
• W114612069 title "Neurite Outgrowth in Retinal Ganglion Cell Culture" @default.
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• W114612069 doi "https://doi.org/10.1385/1-59745-217-3:427" @default.
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