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- W114633106 abstract "The absorption of protein from the pulmonary alveoli may be important in the resolution of congestive and inflammatory disorders of the lung. Previous studies have indicated very slow or no significant pulmonary absorption of protein. The present study, using a sensitive technique, was undertaken to determine the rate at which albumin was removed from the alveoli, and to what extent whole protein was absorbed. Observations were made of the absorption of radioactivity into the plasma from solutions of I/sup 131/-iodide and albumin- bound I/sup 131/ instilled directly into the lungs of normal dogs. Iodide was rapidly absorbed from the lung. Albumin was absorbed more slowly. However, the concentration of absorbed albumin was 2.47 per cent of the dose per 100 ml plasma at 24 hours. Assuming an average plasma volume of 700 ml, the total quantity of albumin absorbed from the lung into the plasma was 5 per cent of the dose af 5 hours and 15 per cent at 24 hours. Separation of the plasma radioactivity into free and albumin-bound fractions indicated that albumin was absorbed from the lung predominantly as intact protein. (auth)" @default.
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- W114633106 date "1963-03-01" @default.
- W114633106 modified "2023-09-23" @default.
- W114633106 title "Absorption of radioactive albumin from the lungs of normal dogs." @default.
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