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- W114665533 abstract "The role of food allergy in EoE may be explained by a breakdown in oral tolerance or a failure in the induction of tolerance. Oral tolerance is the physiologic mechanism by which immune responses to an antigen are suppressed by prior administration of the antigen by the oral route. This normal process is crucial in allowing a wide array of dietary proteins access to the body without activating harmful immune responses. Oral tolerance presumably evolved as an analog of self-tolerance to prevent potentially dangerous hypersensitivity reactions to harmless food proteins and commensal gut flora. The lumen of the gastrointestinal tract, the largest immunologic organ in the body, is continually exposed to numerous dietary proteins. Here, antigen-presenting cells encounter food proteins and subsequently activate regulatory T lymphocytes that reside in the loose connective tissue beneath the gastrointestinal epithelium. These cells then suppress cellular and humoral immune responses to the protein. In nonallergic hosts, the majority of food proteins are absorbed without provoking injurious local or systemic immune responses. The pathologic cellular and humoral immune responses that characterize food allergy likely result from either a failure in establishing tolerance or a breakdown in existing tolerance. It is possible that similar mechanisms underlie the pathogenesis of EoE." @default.
- W114665533 created "2016-06-24" @default.
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- W114665533 date "2011-08-20" @default.
- W114665533 modified "2023-10-14" @default.
- W114665533 title "Oral Tolerance and Eosinophilic Esophagitis" @default.
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- W114665533 doi "https://doi.org/10.1007/978-1-60761-515-6_26" @default.
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