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- W114679113 abstract "Publisher Summary This chapter discusses mutations in the mouse through breeding to homozygosity transgenic mice, resulting from infection of embryos with retroviruses. To date, four recessive lethal mutations have been identified; these manifest their effect at quite different stages of development. Of 70 strains bred to homozygosity, four were found to have recessive lethal mutations. The identity of only one of the four mutated genes is known. In the Movl3 strain, a Moloney murine leukemia virus (M-MuLV) provirus has integrated in the first intron of the αl(I) collagen gene. The effect of this provirus on transcription of this gene and the resulting death of homozygotes at the 12th day of gestation from the rupture of major vessels is well documented. A second mutation (Mov34) was found to arise from the integration of an M-MuLV-derived provirus into an as yet unidentified gene. Embryos homozygous for the Mov34 integration were found to develop normally to blastocysts, and then die after implanting into the uterine wall." @default.
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- W114679113 date "1992-01-01" @default.
- W114679113 modified "2023-09-27" @default.
- W114679113 title "Developmental Mutations Generated by Retroviral Insertional Mutagenesis" @default.
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- W114679113 doi "https://doi.org/10.1016/b978-0-12-293445-2.50008-9" @default.
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