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- W114721404 endingPage "95" @default.
- W114721404 startingPage "81" @default.
- W114721404 abstract "This chapter reviews the attributes and structure of Helicobacter pylori lipopolysaccharides (LPSs), especially the relationship between molecular structure and pathogenesis. The outermost O-specific polysaccharide chain is a polymer of identical repeating units that may contain up to seven different sugars, depending on the bacterial species and strain. Fresh clinical isolates of H. pylori produce highmolecular-weight, smooth-form LPS (S-LPS). Compared with other bacterial species, the core regions of H. pylori strains exhibit an unusual conformation as determined by chemical structural studies. As exemplified by the core oligosaccharide of H. pylori NCTC 11637, a branching occurs from the D-glycero-D-manno-heptose (DD-Hep) residue in the inner core through a second such residue to which the first repeating unit of the O-polysaccharide chain is attached. Survival of H. pylori below pH 4 is dependent on urease activity, whereas urease-independent mechanisms, although less well characterized, operate at greater than pH 4. Bacterial interactions with extracellular and basement membrane proteins play an important role in the pathogenesis and virulence of a number of infections. Elevated pepsinogen, a precursor of mucolytic and barrier-breaking pepsin, is considered a marker for the development and recurrence of duodenal ulcers." @default.
- W114721404 created "2016-06-24" @default.
- W114721404 creator A5074207901 @default.
- W114721404 date "2014-04-09" @default.
- W114721404 modified "2023-10-16" @default.
- W114721404 title "Molecular Structure, Biosynthesis, and Pathogenic Roles of Lipopolysaccharides" @default.
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- W114721404 doi "https://doi.org/10.1128/9781555818005.ch8" @default.
- W114721404 hasPublicationYear "2014" @default.
- W114721404 type Work @default.