FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W114737604> ?p ?o ?g. }

• W114737604 endingPage "397" @default.
• W114737604 startingPage "389" @default.
• W114737604 abstract "The major protein constituent of Lewy bodies (LBs), the pathological hallmark of Parkinson disease and dementia with Lewy bodies, is considered to be α-synuclein, but other proteins, in particular the microtubule-associated protein tau, have been implicated in the pathogenesis of LBs. Tau is the major structural component of neurofibrillary tangles (NFTs). Both direct immunochemical studies of partially purified LBs and indirect immunohistochemical studies have suggested that LBs may contain tau, but most of these studies were based upon a single tau antibody, and immunologic cross-reactivity was not completely excluded. To gain insight into the relation between tau and α-synuclein in LBs, double immunostaining was performed in Lewy body cases with a rabbit polyclonal antibody to α-synuclein and a panel of monoclonal antibodies to phospho- and nonphospho-tau epitopes (Alz50, CP9, CP13, PG5, TG3, PHF1) that spanned the length of the tau molecule. Tau-immunoreactive LBs were present in the medulla in 80% of the cases, irrespective of Braak stage. All tau antibodies recognized at least some LBs, arguing against nonspecific antibody cross-reactivity. In most lesions the tau immunostaining was present at the periphery of the LB. The phospho-tau antibody, TG3, detected more LBs than any of the other tau antibodies. The proportion of LBs with tau immunoreactivity was greatest in neurons vulnerable to NFTs, such as those in the locus ceruleus and basal nucleus of Meynert, and least in neurons resistant to NFTs, such as the dorsal motor nucleus of the vagus in the medulla. The present results suggest that tau may coaggregate with α-synuclein in LBs, especially in neuronal populations vulnerable to both NFTs and LBs." @default.
• W114737604 created "2016-06-24" @default.
• W114737604 creator A5009533777 @default.
• W114737604 creator A5047329905 @default.
• W114737604 creator A5060846269 @default.
• W114737604 creator A5076384999 @default.
• W114737604 creator A5089967003 @default.
• W114737604 date "2003-04-01" @default.
• W114737604 modified "2023-10-16" @default.
• W114737604 title "Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies" @default.
• W114737604 cites W1480786153 @default.
• W114737604 cites W1482198038 @default.
• W114737604 cites W1511517753 @default.
• W114737604 cites W1527671059 @default.
• W114737604 cites W1577877616 @default.
• W114737604 cites W1578645292 @default.
• W114737604 cites W1974361709 @default.
• W114737604 cites W1977440066 @default.
• W114737604 cites W1978065571 @default.
• W114737604 cites W1979268652 @default.
• W114737604 cites W1982487434 @default.
• W114737604 cites W1983988051 @default.
• W114737604 cites W2008234948 @default.
• W114737604 cites W2015020748 @default.
• W114737604 cites W2016473759 @default.
• W114737604 cites W2024041849 @default.
• W114737604 cites W2032767149 @default.
• W114737604 cites W2036755018 @default.
• W114737604 cites W2038389180 @default.
• W114737604 cites W2047206971 @default.
• W114737604 cites W2050922537 @default.
• W114737604 cites W2053063666 @default.
• W114737604 cites W2054848243 @default.
• W114737604 cites W2059261643 @default.
• W114737604 cites W2062250460 @default.
• W114737604 cites W2065536409 @default.
• W114737604 cites W2066155243 @default.
• W114737604 cites W2071881564 @default.
• W114737604 cites W2072878433 @default.
• W114737604 cites W2077422298 @default.
• W114737604 cites W2078680897 @default.
• W114737604 cites W2091265794 @default.
• W114737604 cites W2093322139 @default.
• W114737604 cites W2111565853 @default.
• W114737604 cites W2123056519 @default.
• W114737604 cites W2146432853 @default.
• W114737604 cites W2150656456 @default.
• W114737604 cites W2153536347 @default.
• W114737604 cites W2163665026 @default.
• W114737604 cites W2400982232 @default.
• W114737604 doi "https://doi.org/10.1093/jnen/62.4.389" @default.
• W114737604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12722831" @default.
• W114737604 hasPublicationYear "2003" @default.
• W114737604 type Work @default.
• W114737604 sameAs 114737604 @default.
• W114737604 citedByCount "312" @default.
• W114737604 countsByYear W1147376042012 @default.
• W114737604 countsByYear W1147376042013 @default.
• W114737604 countsByYear W1147376042014 @default.
• W114737604 countsByYear W1147376042015 @default.
• W114737604 countsByYear W1147376042016 @default.
• W114737604 countsByYear W1147376042017 @default.
• W114737604 countsByYear W1147376042018 @default.
• W114737604 countsByYear W1147376042019 @default.
• W114737604 countsByYear W1147376042020 @default.
• W114737604 countsByYear W1147376042021 @default.
• W114737604 countsByYear W1147376042022 @default.
• W114737604 countsByYear W1147376042023 @default.
• W114737604 crossrefType "journal-article" @default.
• W114737604 hasAuthorship W114737604A5009533777 @default.
• W114737604 hasAuthorship W114737604A5047329905 @default.
• W114737604 hasAuthorship W114737604A5060846269 @default.
• W114737604 hasAuthorship W114737604A5076384999 @default.
• W114737604 hasAuthorship W114737604A5089967003 @default.
• W114737604 hasBestOaLocation W1147376041 @default.
• W114737604 hasConcept C142724271 @default.
• W114737604 hasConcept C159654299 @default.
• W114737604 hasConcept C169760540 @default.
• W114737604 hasConcept C185592680 @default.
• W114737604 hasConcept C195616568 @default.
• W114737604 hasConcept C203014093 @default.
• W114737604 hasConcept C204232928 @default.
• W114737604 hasConcept C24998067 @default.
• W114737604 hasConcept C2777916540 @default.
• W114737604 hasConcept C2778670691 @default.
• W114737604 hasConcept C2779097696 @default.
• W114737604 hasConcept C2779134260 @default.
• W114737604 hasConcept C2779734285 @default.
• W114737604 hasConcept C2781404750 @default.
• W114737604 hasConcept C2781449126 @default.
• W114737604 hasConcept C2909432713 @default.
• W114737604 hasConcept C40209533 @default.
• W114737604 hasConcept C4224716 @default.
• W114737604 hasConcept C502032728 @default.
• W114737604 hasConcept C71924100 @default.
• W114737604 hasConcept C86803240 @default.
• W114737604 hasConceptScore W114737604C142724271 @default.
• W114737604 hasConceptScore W114737604C159654299 @default.

• next