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- W114758896 abstract "Myocardial tissue engineering is advancing rapidly towards first-in-man studies. Given the advances in the field it is now indispensable to move the most promising strategies into large animal models and collect pivotal preclinical data to inform the regulators and those performing clinical trials how to conduct these first clinical trials. This chapter introduces the background and rationale for myocardial tissue engineering-based heart failure repair, followed by an overview of the most promising tissue engineering concepts for clinical translation and a discussion of cells and matrix composition of optimized human engineered heart muscle. Finally, arguments for large animal models to simulate clinical outcome are provided." @default.
- W114758896 created "2016-06-24" @default.
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- W114758896 date "2014-01-01" @default.
- W114758896 modified "2023-10-16" @default.
- W114758896 title "Clinical considerations for cardiac tissue engineering" @default.
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- W114758896 doi "https://doi.org/10.1533/9780857096715.2.299" @default.
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