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- W1148149450 abstract "Proc Amer Assoc Cancer Res, Volume 47, 20064542 Purpose: Kruppel-like factor 6 (KLF6) is a ubiquitously expressed zinc finger transcriptional factor, which has been suggested to be a candidate of tumor suppressor gene in some tumors such as prostate cancer and astrocytic glioma. Some experimental studies have suggested that KLF6 is frequently down-regulated and can induce apoptosis in non-small cell lung cancer (NSCLC). Here, we evaluated the clinical significance in resected NSCLC. Methods: A total of 152 completely resected NSCLC patients were reviewed, and KLF6 expression was evaluated immunohistochemically. Results: KLF6 expression status was not significantly correlated with any patient characteristic or any other biomarker (i.e. microvessel density, proliferative activity, or incidence of apoptotic cell death). For all patients, there was no significant difference according to KLF6 expression status(p=0.287). However, subset analysis revealed that positive KLF6 expression was a significant favorable prognosis in node-positive (N1-2) patients (Fig.), especially in p-stage IIIA patients (5-year survival rates, 23.8% for KFL-6-negative and 61.1% for KLF6-positive; p=0.038). A multivariate analysis confirmed that KLF6 status was a significant and independent prognostic factor in node-positive NSCLC. Conclusion: KLF6 was a favorable prognostic factor in node-positive (N0-1) NSCLC, but not in node-negative (N0) disease." @default.
- W1148149450 created "2016-06-24" @default.
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- W1148149450 date "2006-04-15" @default.
- W1148149450 modified "2023-10-02" @default.
- W1148149450 title "KLF6(Krüppel-like factor 6) is a significant prognostic factor in node-positive non-small cell lung cancer (NSCLC)" @default.
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