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- W114863677 abstract "Formation of 8-hydroxyguanine within calf thymus DNA was studied after exposure to uv-H/sub 2/O/sub 2/ as a hydroxyl free-radical generating system. Using high-pressure liquid chromatography with electrochemical detection, the amount of 8-hydroxy-2-deoxyguanosine (8-OHdG) was measured. The 8-OHdG content of uv-exposed DNA increased linearly with increasing H/sub 2/O/sub 2/ levels up to 0.03%, above which the rate of increase was less than linear. All hydroxyl free radical scavengers studied (mannitol, ethanol, thiorea, and salicylate), if present in the system when DNA was exposed to uv-H/sub 2/O/sub 2/, caused a decrease in the amount of 8-OHdG formed. Thiourea when incubated with damaged DNA caused a loss of 8-OHdG when it was an integral part of DNA. In contrast, thiorea did not react with the nucleoside free in solution. Reduced glutathione did not cause a decrease of 8-OHdG, either when it was an integral part of DNA, or as the free nucleoside in solution." @default.
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- W114863677 date "1988-01-01" @default.
- W114863677 modified "2023-09-23" @default.
- W114863677 title "Hydroxyl free-radical mediated formation of 8-hydroxyguanine in isolated DNA (journal version)" @default.
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