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- W11488399 abstract "In these studies we have shown the following: (1) the early neonatal B cell repertoire consists of a highly autoreactive set of B cells showing extensive multispecificity and interconnectivity; (2) many of these antibodies were shown to express antiidiotypic activity toward autologous germ line-encoded idiotypic antibodies; and (3) the antiidiotypic activities of such B cells and/or their antibody products play a major role in the establishment of clonal dominance of certain well-characterized idiotypes in the responses to phosphorylcholine (PC) and α1-3 dextran (DEX). Thus, these results suggest that there are extensive idiotype-directed interactions between B cells early during development which appear to be essential for the establishment of the adult B cell repertoire and the accompanying clonal dominance of appropriate idiotypes." @default.
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- W11488399 date "1986-01-01" @default.
- W11488399 modified "2023-09-26" @default.
- W11488399 title "Idiotype-Directed Interactions during B Cell Ontogeny" @default.
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- W11488399 doi "https://doi.org/10.1016/b978-0-12-174685-8.50039-1" @default.
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