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- W1149318881 abstract "Objective:To investigate the effects of 6 strains of lactobacilli and their main culture metabolites on the morphogenesis of Candida albicans (C. albicans) so as to screen medicinal strains as antifungal agents. Methods: Spent culture supernatant (SC'S) at different culture time points, live lactobacilli, heat-killed bacteria and bacterial short-chain fatty acids (SCFA) with different molarities were incubated with C. albicans respectively. Crystal violet-based germ tube assay was used to detect the germination of C. al-bicans and the inhibitory efficiency of each addition was tested by germination rate. Results: SCS of lacto-bacillus spp. decreased the germination significantly and live bacteria of L. rhamnosus. GG, L. acidophilus 1.050103-12 as well as L. johnsonii JCM1022 could partially inhibit the conversion, however, all the heat-killed bacteria failed to control the germ tube formation. In addition, only butyric acid blocked the conversion of yeast to hypha among all the SCFA. Conclusion: The excellent fungistasis activities make L. rhamnosus. GG. L. acidophilus L050103 12 and L. johnsonii JCM1022 potential strains as antifungal drugs and the inhibition seems to have direct correlation to the metabolites." @default.
- W1149318881 created "2016-06-24" @default.
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- W1149318881 date "2006-01-01" @default.
- W1149318881 modified "2023-09-23" @default.
- W1149318881 title "Inhibition of germ tube's formation of Candida albicans by lactobacillus spp." @default.
- W1149318881 hasPublicationYear "2006" @default.
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