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• W1150151906 abstract "A series of tetraarylimidazoles (5A-5O) were prepared by one pot four component condensation reactions of 2-arylindole-3-carbaldehydes, substituted anilines, benzil and ammonium acetate in acetic acid. The synthesized compounds exhibited potent antiurease activity with IC50 values ranging from 0.12 ± 0.06 μM to 29.12 ± 0.18 μM as compared with thiourea. However, low inhibition profiles were observed for lipoxygenase. The data show that tetraarylimidazoles containing a substituted 2-penylindole have emerged as a new class of potent inhibitors of urease enzyme." @default.
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• W1150151906 date "2015-09-01" @default.
• W1150151906 modified "2023-10-16" @default.
• W1150151906 title "Discovery of indole-based tetraarylimidazoles as potent inhibitors of urease with low antilipoxygenase activity" @default.
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• W1150151906 doi "https://doi.org/10.1016/j.ejmech.2015.08.011" @default.
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