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- W1150989875 abstract "This chapter discusses the high level of interest in the physiology and pharmacology of potassium (K+) channels, the structure–activity relationships of compounds that modulate such channels, and the diverse indications for these agents. There has been an enormous growth of interest in the area since the elucidation of the mechanism of action of cromakalim—that is, the action enhancing the movement of potassium ions through smooth muscle cell membranes. Potassium channel activators (KCAs) inhibit spontaneous tone in portal vein or contractions evoked by a range of spasmogens in arterial preparations. KCAs shorten the action potential duration and produce a negative inotropic effect in cardiac tissues. These events have been observed at concentrations higher than those required to produce vasorelaxation, indicating selectivity for the vascular smooth muscle. The ability to shorten auditory processing disorder (APD) and to decrease automaticity to arrhythmogenic stimuli has suggested that KCAs may have potential as antiarrhythmic agents. The effects of KCAs on airways, gastrointestinal smooth muscle, detrusor and ureter smooth muscle, uterine smooth muscle, the central nervous system (CNS), and other tissues are also discussed in the chapter." @default.
- W1150989875 created "2016-06-24" @default.
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- W1150989875 date "1991-01-01" @default.
- W1150989875 modified "2023-09-25" @default.
- W1150989875 title "Chapter 8. Potassium Channel Activators" @default.
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- W1150989875 doi "https://doi.org/10.1016/s0065-7743(08)61195-1" @default.
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