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- W11510412 abstract "BACKGROUND Many studies support a role for n-3 polyunsaturated fatty acids (n-3 PUFA) in prevention or inhibition of breast cancer. N-3 PUFA, present abundantly in fish, reduces susceptibility to breast cancer. Among the most well-known n-3 PUFA are eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), linolenic acid and 2,2-bis(4- (4-amino-3-hydroxyphenoxy)phenyl)adamantine (DPA) are of n-3 PUFA. N-3 PUFA DPA is preferentially accumulated in the mammary gland during pregnancy and can be positively correlated with the concurrent induction of mammary differentiation. AIM OF THE STUDY To examine the possible association of fatty acids with breast cancer risk, we examined the effects of EPA, DPA and DHA on the human breast cancer cells. METHODS For RNA and protein isolation, a breast tumor cells, K259 were cultured on non-coating plate. Cells were plated on Matrigel-coated dishes for morphological examination. Cells were treated with EPA, DHA and DPA at 10 or 50 μM for 48 hrs. Extraction proteins were subject to Western Blot for mismatch repair gene (MRG), a previously identified mammary differentiation factor. For quantitative analysis of MRG, isolated RNA was used in subsequent real-time PCR. RESULTS All three n-3 PUFA stimulated MRG expression to various levels. DPA treatment resulted in more than a 50% increase in MRG message level. A more pronounced increase in MRG protein level was observed in response to DPA. CONCLUSIONS Our data indicate that n-3 fatty acid can be cause of pregnancy-induced mammary differentiation. The potential preventing breast cancer by dietary supplements is of practical interest to high risk breast cancer." @default.
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- W11510412 date "2006-03-01" @default.
- W11510412 modified "2023-09-26" @default.
- W11510412 title "Exogenous supplementation with n‐3 fatty acid Enhances mammary differentiation in human breast cancer cells" @default.
- W11510412 doi "https://doi.org/10.1096/fasebj.20.5.lb103-c" @default.
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