FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W115106139> ?p ?o ?g. }

• W115106139 endingPage "207" @default.
• W115106139 startingPage "187" @default.
• W115106139 abstract "Phosphoinositides are membrane-bound signaling phospholipids that function in a myriad of cellular processes, including membrane trafficking, cytoskeletal dynamics, ion channel and transporter function, and signal transduction. In order to better understand the role of phosphoinositides in cellular processes, different approaches to study the effects of the presence or absence of these lipids must be devised. Conventional approaches of manipulating phosphoinositide levels such as over-expression or genetic ablation of lipid enzymes cause prolonged exposure of the cells to changes in lipid levels that could result in compensatory actions by the cell or downstream alterations in cell physiology. In this chapter we present an approach used recently by various laboratories, including our own, to acutely manipulate phosphoinositide levels at target locations using chemically induced dimerization (CID) that can be spatially and temporally controlled. We discuss considerations when designing expression constructs for targeting specific cellular compartment membranes and present examples from the literature on different ways of perturbing phosphoinositide levels at particular organelle membranes using CID. In addition, we provide details on image acquisition, data collection, and data interpretation. CID technology can be applied to many lipid enzymes to broaden the understanding of the role lipid signaling plays in cell physiology." @default.
• W115106139 created "2016-06-24" @default.
• W115106139 creator A5011060359 @default.
• W115106139 creator A5067080780 @default.
• W115106139 creator A5073890226 @default.
• W115106139 date "2012-01-01" @default.
• W115106139 modified "2023-10-13" @default.
• W115106139 title "Acute Manipulation of Phosphoinositide Levels in Cells" @default.
• W115106139 cites W1489145507 @default.
• W115106139 cites W1643436907 @default.
• W115106139 cites W1963813765 @default.
• W115106139 cites W1965940344 @default.
• W115106139 cites W1979797395 @default.
• W115106139 cites W1980445622 @default.
• W115106139 cites W1984754431 @default.
• W115106139 cites W1985287781 @default.
• W115106139 cites W1987005832 @default.
• W115106139 cites W1997784032 @default.
• W115106139 cites W1998038367 @default.
• W115106139 cites W2000424064 @default.
• W115106139 cites W2000994188 @default.
• W115106139 cites W2002194264 @default.
• W115106139 cites W2003787585 @default.
• W115106139 cites W2005392387 @default.
• W115106139 cites W2007110714 @default.
• W115106139 cites W2007513923 @default.
• W115106139 cites W2013131355 @default.
• W115106139 cites W2015140940 @default.
• W115106139 cites W2015536770 @default.
• W115106139 cites W2016955606 @default.
• W115106139 cites W2023815703 @default.
• W115106139 cites W2024428899 @default.
• W115106139 cites W2024797145 @default.
• W115106139 cites W2028679396 @default.
• W115106139 cites W2029354255 @default.
• W115106139 cites W2029852810 @default.
• W115106139 cites W2035074820 @default.
• W115106139 cites W2043206871 @default.
• W115106139 cites W2043312574 @default.
• W115106139 cites W2043597075 @default.
• W115106139 cites W2046006788 @default.
• W115106139 cites W2047112668 @default.
• W115106139 cites W2051053786 @default.
• W115106139 cites W2052082800 @default.
• W115106139 cites W2053527054 @default.
• W115106139 cites W2055659589 @default.
• W115106139 cites W2056189730 @default.
• W115106139 cites W2056988421 @default.
• W115106139 cites W2058553382 @default.
• W115106139 cites W2059928566 @default.
• W115106139 cites W2064746504 @default.
• W115106139 cites W2064894346 @default.
• W115106139 cites W2066796289 @default.
• W115106139 cites W2072317853 @default.
• W115106139 cites W2072530403 @default.
• W115106139 cites W2077283557 @default.
• W115106139 cites W2082492086 @default.
• W115106139 cites W2082688327 @default.
• W115106139 cites W2084764067 @default.
• W115106139 cites W2089094879 @default.
• W115106139 cites W2090469070 @default.
• W115106139 cites W2091884933 @default.
• W115106139 cites W2092364334 @default.
• W115106139 cites W2093587379 @default.
• W115106139 cites W2094149522 @default.
• W115106139 cites W2099721577 @default.
• W115106139 cites W2102580914 @default.
• W115106139 cites W2106699401 @default.
• W115106139 cites W2108077848 @default.
• W115106139 cites W2108586733 @default.
• W115106139 cites W2110221241 @default.
• W115106139 cites W2111192516 @default.
• W115106139 cites W2113755495 @default.
• W115106139 cites W2115921046 @default.
• W115106139 cites W2117649547 @default.
• W115106139 cites W2117707098 @default.
• W115106139 cites W2119809698 @default.
• W115106139 cites W2123298030 @default.
• W115106139 cites W2124593509 @default.
• W115106139 cites W2124804382 @default.
• W115106139 cites W2124833370 @default.
• W115106139 cites W2126496496 @default.
• W115106139 cites W2135450099 @default.
• W115106139 cites W2137382396 @default.
• W115106139 cites W2139094884 @default.
• W115106139 cites W2144420636 @default.
• W115106139 cites W2148024451 @default.
• W115106139 cites W2153841101 @default.
• W115106139 cites W2155151508 @default.
• W115106139 cites W2166348969 @default.
• W115106139 cites W4253230296 @default.
• W115106139 cites W4298134572 @default.
• W115106139 doi "https://doi.org/10.1016/b978-0-12-386487-1.00010-9" @default.
• W115106139 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3543678" @default.
• W115106139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22325604" @default.
• W115106139 hasPublicationYear "2012" @default.
• W115106139 type Work @default.
• W115106139 sameAs 115106139 @default.

• next