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• W115127599 abstract "Palmitate induces cell death in cardiomyocytes. Both apoptotic and oncotic death is produced by palmitate. However, apoptotic death was the only one of the two forms of cell death that was subject to modification. Palmitate induced several mitochondrial changes, most notably a loss of mitochondrial permeability with cytochrome c release and a loss of mitochondrial function. These data suggest that palmitate-induced cell death is mediated, at least in part, through mitochondria. A role for the mitochondria is further established by the data that CPT-1, the initial step in the transport of palmitate into the mitochondria, is an important step in palmitate-induced apoptosis. Thus data suggesting that a metabolic product of palmitate metabolism, that occurs in the mitochondria, is responsible for palmitate-induced cell death." @default.
• W115127599 created "2016-06-24" @default.
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• W115127599 date "2003-01-01" @default.
• W115127599 modified "2023-09-22" @default.
• W115127599 title "Mechanisms of Palmitate-induced Cardiomyocyte Apoptosis" @default.
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• W115127599 doi "https://doi.org/10.1007/978-1-4419-9262-8_30" @default.
• W115127599 hasPublicationYear "2003" @default.
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