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- W115144449 abstract "Abstract T regulatory cells [Tregs] play an important role in controlling autoimmunity. The NOD mouse provides an excellent model to delineate the role of Tregs. Transfer experiments have shown that Tregs can prevent the progression of T1D. Similar results were obtained from depletion of Tregs in vivo. However, quantitative and qualitative changes in Tregs with the progression of T1D have not been examined in detail. In this study we studied changes in number and function of Tregs during progression of T1D in NOD. Since NOD males and females are very similar, yet the incidence of diabetes in males is much lower than the females, we examined sex based differences in Tregs and effectors. We examined the expression of CD4+CD25+FoxP3+ to define the quantitative differences in Tregs. Time-course analysis showed that Treg numbers remained constant or slightly increased from 6 week to 16 weeks of age. Also, both female and male NOD had similar numbers of Tregs, suggesting that T1D progression is not due to a quantitative change in Tregs. Functional assays for purified Tregs from both male and female NOD showed marginal differences between their activities in vitro and in vivo. We found that islet-reactive T cells from female NOD were more auto-aggressive and refractory to regulation by Tregs than male effectors. These data suggest, for the first time, that refractory effector T cells, and not the number or function of Tregs, may account for T1D." @default.
- W115144449 created "2016-06-24" @default.
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- W115144449 date "2007-04-01" @default.
- W115144449 modified "2023-09-27" @default.
- W115144449 title "Reduced sensitivity of effectors to regulation, and not reduced Treg function, may lead to autoimmune diabetes in NOD (128.1)" @default.
- W115144449 doi "https://doi.org/10.4049/jimmunol.178.supp.128.1" @default.
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