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- W1151814897 abstract "Central systolic and pulse pressures, indicative of changes in large conduit and small resistance arteries, are independent determinants of organ damage and might represent a main target of antihypertensive treatment. We superimpose here a pharmacological approach on our previous pathophysiological one. First, we review the effects of various drugs on the structural and functional properties of large and small arteries. Then we explain how some pharmacological classes can reverse the vicious circle of aggravation into a virtuous circle of improvement. We focus on antihypertensive drugs, because they have been the most studied, and we emphasize clinical pharmacology. Among antihypertensive drugs, β-blockers, and diuretics have a negligible effect on microvascular structure, while renin–angiotensin system blockers and calcium entry blockers have favorable actions: improved small artery remodeling, reduced large artery stiffness, and lowered central systolic and pulse pressures." @default.
- W1151814897 created "2016-06-24" @default.
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- W1151814897 date "2015-01-01" @default.
- W1151814897 modified "2023-10-18" @default.
- W1151814897 title "Targeting Central Blood Pressure Through the Macro- and Microcirculation Cross-Talk" @default.
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- W1151814897 doi "https://doi.org/10.1016/b978-0-12-801387-8.00028-4" @default.
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