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- W1152290614 endingPage "29" @default.
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- W1152290614 abstract "Opiate receptor is used to designate areas of the brain, having a specific affinity for opiate agonists and antagonists. Endogenous peptides called enkephalins and endorphins can react with the opiate receptor to produce opiate effects. The effects of these peptides are antagonized by naloxone. Synthetic analgesics like the morphinans and the benzomorphans are capable of interacting in a specific way with receptors in the central nervous system (CNS), depending on the irrelative agonist or antagonist properties. The endogenous opioids are not only involved in analgesia but also play a role in mental diseases, such as schizophrenia and depression. Naloxone reverses the catatonia and hypothermia produced by brain peptides in animals and in humans. Eenkephalin is proposed as a neurotransmitter, and its binding to opiate receptors determine the mood state and influence respiratory and sleep patterns. Lithium acts through the modification of the binding of the endogenous morphine-like substances at the opiate receptor. The endorphins are defined as a class of opioid acting peptides isolated from the brain. Naloxone blocks food-seeking and water-seeking behavior in hungry or thirsty rats. Stimulation of the central gray region in humans has produced marked analgesia that is antagonized by naloxone. A subset of the endorphins is called enkephalins. Anodynin differs from the enkephalins in its longer duration of action, its lack of susceptibility to enzymatic splitting, its thin layer mobility, its behavioral effects, and its apparent ability to cross the blood brain barrier. In man, azidomorphine constrict pupils, produces morphine-like subjective effects and euphoria, and suppress the morphine abstinence syndrome." @default.
- W1152290614 created "2016-06-24" @default.
- W1152290614 creator A5005534384 @default.
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- W1152290614 date "1977-01-01" @default.
- W1152290614 modified "2023-09-25" @default.
- W1152290614 title "Chapter 3. Analgesics, Antagonists, the Opiate Receptor and Endogenous Opioids" @default.
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