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- W115273236 abstract "The sensory systems preserve the topography of stimuli by creating spatially ordered connections, or “maps” in the brain. The visual system has been a prototypical system for the study of mapping of spatial information onto appropriate areas of the brain. The retinal ganglion cell axons form terminal arbors in the contralateral optic tectum, and these arbors are ordered. Axons from a specific region of the retina project in a predictable manner to a specific region in the tectum. Sperry (1963) brought the problems of the formation of an orderly array of synaptic connections sharply into focus in his now-classic paper describing the chemoaffinity hypothesis which proposed fiber-to-target interactions and suggested that afferents were tagged with a biochemical label, synapsing only with neurons that carry a complementary label. Since Sperry’s seminal paper, the concept of chemoaffinity has been expanded and additional theories of pattern formation have been proposed, including such examples of the following:" @default.
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- W115273236 date "1993-01-01" @default.
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- W115273236 title "Neural Specificity Revisited" @default.
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