Matches in SemOpenAlex for { <https://semopenalex.org/work/W1153128721> ?p ?o ?g. }
- W1153128721 endingPage "319" @default.
- W1153128721 startingPage "313" @default.
- W1153128721 abstract "Aortic valve stenosis is the most common valvular disease in the elderly population. Presently, there is increasing evidence that aortic stenosis (AS) is an active process of lipid deposition, inflammation, fibrosis and calcium deposition. The pathogenesis of AS shares many similarities to that of atherosclerosis; therefore, it was hypothesized that certain lipid interventions could prevent or slow the progression of aortic valve stenosis. Despite the early enthusiasm that statins may slow the progression of AS, recent large clinical trials did not consistently demonstrate a decrease in the progression of AS. However, some researchers believe that statins may have a benefit early on in the disease process, where inflammation (and not calcification) is the predominant process, in contrast to severe or advanced AS, where calcification (and not inflammation) predominates. Positron emission tomography using 18F-fluorodeoxyglucose and 18F-sodium fluoride can demonstrate the relative contributions of valvular calcification and inflammation in AS, and thus this method might potentially be useful in providing the answer as to whether lipid interventions at the earlier stages of AS would be more effective in slowing the progression of the disease. Currently, there is a strong interest in recombinant apolipoprotein A-1 Milano and in the development of new pharmacological agents, targeting reduction of lipoprotein (a) levels and possibly reduction of the expression of lipoprotein-associated phospholipase A2, as potential means to slow the progression of aortic valvular stenosis." @default.
- W1153128721 created "2016-06-24" @default.
- W1153128721 creator A5011051172 @default.
- W1153128721 creator A5028552410 @default.
- W1153128721 creator A5040121452 @default.
- W1153128721 creator A5046358640 @default.
- W1153128721 creator A5068998296 @default.
- W1153128721 creator A5084306618 @default.
- W1153128721 date "2015-10-01" @default.
- W1153128721 modified "2023-09-25" @default.
- W1153128721 title "Lipid Interventions in Aortic Valvular Disease" @default.
- W1153128721 cites W1479880028 @default.
- W1153128721 cites W1507413178 @default.
- W1153128721 cites W1516536249 @default.
- W1153128721 cites W1525331105 @default.
- W1153128721 cites W1574373575 @default.
- W1153128721 cites W170643099 @default.
- W1153128721 cites W193780144 @default.
- W1153128721 cites W1963621262 @default.
- W1153128721 cites W1963913523 @default.
- W1153128721 cites W1965418020 @default.
- W1153128721 cites W1975564959 @default.
- W1153128721 cites W1977784046 @default.
- W1153128721 cites W1978366710 @default.
- W1153128721 cites W1980298827 @default.
- W1153128721 cites W1984222785 @default.
- W1153128721 cites W1988571789 @default.
- W1153128721 cites W1990063973 @default.
- W1153128721 cites W1990204315 @default.
- W1153128721 cites W1994219871 @default.
- W1153128721 cites W1994287402 @default.
- W1153128721 cites W1998308564 @default.
- W1153128721 cites W2007710555 @default.
- W1153128721 cites W2009437551 @default.
- W1153128721 cites W2009500759 @default.
- W1153128721 cites W2011126362 @default.
- W1153128721 cites W2017088706 @default.
- W1153128721 cites W2031537089 @default.
- W1153128721 cites W2039182800 @default.
- W1153128721 cites W2043353709 @default.
- W1153128721 cites W2048919425 @default.
- W1153128721 cites W2051575384 @default.
- W1153128721 cites W2053171963 @default.
- W1153128721 cites W2053391717 @default.
- W1153128721 cites W2054375155 @default.
- W1153128721 cites W2063982755 @default.
- W1153128721 cites W2070396041 @default.
- W1153128721 cites W2071124826 @default.
- W1153128721 cites W2071238583 @default.
- W1153128721 cites W2076890216 @default.
- W1153128721 cites W2077792958 @default.
- W1153128721 cites W2080493013 @default.
- W1153128721 cites W2086153196 @default.
- W1153128721 cites W2087033359 @default.
- W1153128721 cites W2095808083 @default.
- W1153128721 cites W2098019869 @default.
- W1153128721 cites W2098230963 @default.
- W1153128721 cites W2098890974 @default.
- W1153128721 cites W2098946775 @default.
- W1153128721 cites W2101207877 @default.
- W1153128721 cites W2101257910 @default.
- W1153128721 cites W2101264497 @default.
- W1153128721 cites W2104974378 @default.
- W1153128721 cites W2106452931 @default.
- W1153128721 cites W2107134698 @default.
- W1153128721 cites W2117330772 @default.
- W1153128721 cites W2118154631 @default.
- W1153128721 cites W2125711853 @default.
- W1153128721 cites W2133438216 @default.
- W1153128721 cites W2138402059 @default.
- W1153128721 cites W2140951702 @default.
- W1153128721 cites W2140978366 @default.
- W1153128721 cites W2144258039 @default.
- W1153128721 cites W2147032424 @default.
- W1153128721 cites W2148706200 @default.
- W1153128721 cites W2158110141 @default.
- W1153128721 cites W2161821089 @default.
- W1153128721 cites W2165687659 @default.
- W1153128721 cites W2166083928 @default.
- W1153128721 cites W2167045683 @default.
- W1153128721 cites W2170252961 @default.
- W1153128721 cites W2322095705 @default.
- W1153128721 cites W2551740633 @default.
- W1153128721 cites W38523360 @default.
- W1153128721 cites W4235797558 @default.
- W1153128721 doi "https://doi.org/10.1097/maj.0000000000000544" @default.
- W1153128721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26263237" @default.
- W1153128721 hasPublicationYear "2015" @default.
- W1153128721 type Work @default.
- W1153128721 sameAs 1153128721 @default.
- W1153128721 citedByCount "4" @default.
- W1153128721 countsByYear W11531287212016 @default.
- W1153128721 countsByYear W11531287212019 @default.
- W1153128721 countsByYear W11531287212023 @default.
- W1153128721 crossrefType "journal-article" @default.
- W1153128721 hasAuthorship W1153128721A5011051172 @default.
- W1153128721 hasAuthorship W1153128721A5028552410 @default.
- W1153128721 hasAuthorship W1153128721A5040121452 @default.