FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1153313479> ?p ?o ?g. }

• W1153313479 endingPage "93" @default.
• W1153313479 startingPage "77" @default.
• W1153313479 abstract "Background/Aims: CD117+ stem cell (SC) based therapy is considered an alternative therapeutic option for terminal heart disease. However, controversies exist on the effects of CD117+ SC implantation. In particular, the link between CD117+ SC function and angiotensin-II-type-2 receptor (AT2R) after MI is continuously discussed. We therefore asked whether 1) AT2R stimulation influences CD117+ SC properties in vitro and, 2) which effects can be ascribed to AT2R stimulation in vivo. Methods: We approached AT2R stimulation with Angiotensin II while simultaneously blocking its opponent receptor AT1 with Losartan. CD117 effects were dissected using a 2D-Matrigel assay and HL-1 co-culture in vitro. A model of myocardial infarction, in which we implanted EGFP+ CD117 SC, was further applied. Results: While we found indications for AT2R driven vasculogenesis in vitro, co-culture experiments revealed that CD117+ SC improve vitality of cardiomyocytes independently of AT2R function. Likewise, untreated CD117+ SC had a positive effect on cardiac function and acted cardioprotective in vivo. Conclusions: Therefore, our data show that transient AT2R stimulation does not significantly add to the beneficial actions of CD117+ SC in vivo. Yet, exploiting AT2R driven vasculogenis via an optimized AT2R stimulation protocol may become a promising tool for cardiac SC therapy." @default.
• W1153313479 created "2016-06-24" @default.
• W1153313479 creator A5013959327 @default.
• W1153313479 creator A5035005191 @default.
• W1153313479 creator A5038809102 @default.
• W1153313479 creator A5046008381 @default.
• W1153313479 creator A5047568386 @default.
• W1153313479 creator A5055249856 @default.
• W1153313479 creator A5058708835 @default.
• W1153313479 creator A5062218486 @default.
• W1153313479 date "2015-01-01" @default.
• W1153313479 modified "2023-09-27" @default.
• W1153313479 title "Exploiting AT2R to Improve CD117 Stem Cell Function In Vitro and In Vivo - Perspectives for Cardiac Stem Cell Therapy" @default.
• W1153313479 cites W1517126484 @default.
• W1153313479 cites W160771735 @default.
• W1153313479 cites W1631250427 @default.
• W1153313479 cites W1963662096 @default.
• W1153313479 cites W1971541054 @default.
• W1153313479 cites W1971778857 @default.
• W1153313479 cites W1975589289 @default.
• W1153313479 cites W1976120430 @default.
• W1153313479 cites W1976843785 @default.
• W1153313479 cites W1977019074 @default.
• W1153313479 cites W1977872287 @default.
• W1153313479 cites W1979582673 @default.
• W1153313479 cites W1983517713 @default.
• W1153313479 cites W1983840318 @default.
• W1153313479 cites W1987885331 @default.
• W1153313479 cites W2000838901 @default.
• W1153313479 cites W2026019936 @default.
• W1153313479 cites W2029998052 @default.
• W1153313479 cites W2033325833 @default.
• W1153313479 cites W2041119309 @default.
• W1153313479 cites W2044432093 @default.
• W1153313479 cites W2050700175 @default.
• W1153313479 cites W2051747980 @default.
• W1153313479 cites W2053355747 @default.
• W1153313479 cites W2058195291 @default.
• W1153313479 cites W2065226637 @default.
• W1153313479 cites W2071172710 @default.
• W1153313479 cites W2077120542 @default.
• W1153313479 cites W2084693500 @default.
• W1153313479 cites W2087935545 @default.
• W1153313479 cites W2090041902 @default.
• W1153313479 cites W2092377409 @default.
• W1153313479 cites W2096227522 @default.
• W1153313479 cites W2109921861 @default.
• W1153313479 cites W2111704063 @default.
• W1153313479 cites W2112903359 @default.
• W1153313479 cites W2114754360 @default.
• W1153313479 cites W2121863989 @default.
• W1153313479 cites W2124396531 @default.
• W1153313479 cites W2134899427 @default.
• W1153313479 cites W2138291237 @default.
• W1153313479 cites W2140852350 @default.
• W1153313479 cites W2143116260 @default.
• W1153313479 cites W2155997935 @default.
• W1153313479 cites W2156482931 @default.
• W1153313479 cites W2160024670 @default.
• W1153313479 cites W2162412444 @default.
• W1153313479 cites W2166040185 @default.
• W1153313479 cites W2168535680 @default.
• W1153313479 cites W2318716881 @default.
• W1153313479 cites W2333501836 @default.
• W1153313479 cites W103429211 @default.
• W1153313479 doi "https://doi.org/10.1159/000430335" @default.
• W1153313479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26303045" @default.
• W1153313479 hasPublicationYear "2015" @default.
• W1153313479 type Work @default.
• W1153313479 sameAs 1153313479 @default.
• W1153313479 citedByCount "8" @default.
• W1153313479 countsByYear W11533134792016 @default.
• W1153313479 countsByYear W11533134792017 @default.
• W1153313479 countsByYear W11533134792019 @default.
• W1153313479 countsByYear W11533134792021 @default.
• W1153313479 countsByYear W11533134792023 @default.
• W1153313479 crossrefType "journal-article" @default.
• W1153313479 hasAuthorship W1153313479A5013959327 @default.
• W1153313479 hasAuthorship W1153313479A5035005191 @default.
• W1153313479 hasAuthorship W1153313479A5038809102 @default.
• W1153313479 hasAuthorship W1153313479A5046008381 @default.
• W1153313479 hasAuthorship W1153313479A5047568386 @default.
• W1153313479 hasAuthorship W1153313479A5055249856 @default.
• W1153313479 hasAuthorship W1153313479A5058708835 @default.
• W1153313479 hasAuthorship W1153313479A5062218486 @default.
• W1153313479 hasBestOaLocation W11533134791 @default.
• W1153313479 hasConcept C10205521 @default.
• W1153313479 hasConcept C123915805 @default.
• W1153313479 hasConcept C126322002 @default.
• W1153313479 hasConcept C150903083 @default.
• W1153313479 hasConcept C170493617 @default.
• W1153313479 hasConcept C185592680 @default.
• W1153313479 hasConcept C207001950 @default.
• W1153313479 hasConcept C24998067 @default.
• W1153313479 hasConcept C2776839831 @default.
• W1153313479 hasConcept C28328180 @default.
• W1153313479 hasConcept C2908929049 @default.
• W1153313479 hasConcept C71924100 @default.

• next